A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis - A phase I clinical trial

UNLABELLED: Uveitis is a T cell-mediated, intraocular inflammatory disease and one of the main causes of blindness in industrialized countries. There is a high unmet need for new immunomodulatory, steroid-sparing therapies, since only ciclosporin A and a single TNF-α-blocker are approved for non-inf...

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Veröffentlicht in:	FRONTIERS IN MEDICINE 2022-10, Vol.9
Hauptverfasser:	Thurau, Stephan, Deuter, Christoph M.E, Heiligenhaus, Arnd, Pleyer, Uwe, Van Calster, Joachim, Barisani-Asenbauer, Talin, Obermayr, Franz, Sperl, Stefan, Seda-Zehetner, Romana, Wildner, Gerhild
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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