Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma

BACKGROUND: Loss of Ambra1 (autophagy and beclin 1 regulator 1), a multifunctional scaffold protein, promotes the formation of nevi and contributes to several phases of melanoma development. The suppressive functions of Ambra1 in melanoma are mediated by negative regulation of cell proliferation and...

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Veröffentlicht in:	JOURNAL FOR IMMUNOTHERAPY OF CANCER 2023-03, Vol.11 (3)
Hauptverfasser:	Frias, Alex, Di Leo, Luca, Antoranz, Asier, Nazerai, Loulieta, Carretta, Marco, Bodemeyer, Valerie, Pagliuca, Chiara, Dahl, Christina, Claps, Giuseppina, Mandelli, Giulio Eugenio, Andhari, Madhavi Dipak, Pacheco, Maria Pires, Sauter, Thomas, Robert, Caroline, Guldberg, Per, Madsen, Daniel Hargbol, Cecconi, Francesco, Bosisio, Francesca Maria, De Zio, Daniela
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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