Absolute Quantification of Residual Solvent in Mesoporous Silica Drug Formulations Using Magic-Angle Spinning NMR Spectroscopy

Porous silica is used as a drug delivery agent to improve the bioavailability of sparsely soluble compounds. In this approach, the active pharmaceutical ingredient (API) is commonly loaded into the porous silica by incipient wetness impregnation using organic solvents. Subsequent solvent elimination...

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Veröffentlicht in:	Analytical Chemistry 2022-12, Vol.95 (3), p.1880-1887
Hauptverfasser:	Vanderschaeghe, Hannah, Houlleberghs, Maarten, Verheyden, Loes, Dom, Dirk, Chandran, C. Vinod, Radhakrishnan, Sambhu, Martens, Johan A, Breynaert, Eric
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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