Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

DNA oxidation by ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming. The conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) initiates developmental and cell-type-specific transcriptional programs through mechanisms that include changes in th...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ELIFE 2022-02, Vol.11
Hauptverfasser:	Sabino, Joao C, de Almeida, Madalena R, Abreu, Patricia L, Ferreira, Ana M, Caldas, Paulo, Domingues, Marco M, Santos, Nuno C, Azzalin, Claus M, Grosso, Ana Rita, de Almeida, Sergio Fernandes
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!