Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer
PURPOSE: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. METHODS: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurren...
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| Veröffentlicht in: | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2022-09, Vol.148 (9), p.2231-2234 |
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| creator | Fankhauser, Christian D de Vries, Hielke M Roussel, Eduard Jakobsen, Jakob Kristian Issa, Allaudin Lee, Esther W.C Schifano, Nicolo Alnajjar, Hussain Castiglione, Fabio Antonelli, Luca Oliveira, Pedro Lau, Maurice Parnham, Arie Albersen, Maarten Watkin, Nicholas A Muneer, Asif Ayres, Ben E Brouwer, Oscar R Sangar, Vijay |
| description | PURPOSE: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. METHODS: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed. RESULTS: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value |
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| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_20_500_12942_693771</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20_500_12942_693771</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_20_500_12942_6937713</originalsourceid><addsrcrecordid>eNqVjM1KAzEUhbNQsFbf4a4LlSTjdOi6-LNw2X24ZO7Y2PRmyE2qfXsj-AAKBw6H7_BdqYU2g1n31mxu1K3Ih267H-xCXd4up_mQzii-RsyAPMJMOTDVjBECNxISA2aCHOQIE_qSssCUcqPvNXC7xR8JcBoJTlRQWkgabovhM5QD7M2LbWIOkcAje8p36nrCKHT_20u1en7a717XxxqpnondKDN6cla7Xmtn7PbRus22GwbTLdXDn8-ufJXuX_ZvqM9fAQ</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer</title><source>Lirias (KU Leuven Association)</source><source>SpringerNature Journals</source><creator>Fankhauser, Christian D ; de Vries, Hielke M ; Roussel, Eduard ; Jakobsen, Jakob Kristian ; Issa, Allaudin ; Lee, Esther W.C ; Schifano, Nicolo ; Alnajjar, Hussain ; Castiglione, Fabio ; Antonelli, Luca ; Oliveira, Pedro ; Lau, Maurice ; Parnham, Arie ; Albersen, Maarten ; Watkin, Nicholas A ; Muneer, Asif ; Ayres, Ben E ; Brouwer, Oscar R ; Sangar, Vijay</creator><creatorcontrib>Fankhauser, Christian D ; de Vries, Hielke M ; Roussel, Eduard ; Jakobsen, Jakob Kristian ; Issa, Allaudin ; Lee, Esther W.C ; Schifano, Nicolo ; Alnajjar, Hussain ; Castiglione, Fabio ; Antonelli, Luca ; Oliveira, Pedro ; Lau, Maurice ; Parnham, Arie ; Albersen, Maarten ; Watkin, Nicholas A ; Muneer, Asif ; Ayres, Ben E ; Brouwer, Oscar R ; Sangar, Vijay</creatorcontrib><description>PURPOSE: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. METHODS: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed. RESULTS: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value < 0.01) Tumour size was not associated with ILN risk (OR 1.01 95% CI 0.99-1.04, p = 0.17). CONCLUSION: Approximately, one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still have ILN metastases despite being clinically node negative. Therefore, invasive ILN staging should strongly be recommended in T1G2 with LVI + or PNI + but importantly, must be discussed in patients with T1G2 with LVI- or PNI-.</description><identifier>ISSN: 0171-5216</identifier><language>eng</language><publisher>SPRINGER</publisher><ispartof>JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2022-09, Vol.148 (9), p.2231-2234</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,780,784,27860</link.rule.ids></links><search><creatorcontrib>Fankhauser, Christian D</creatorcontrib><creatorcontrib>de Vries, Hielke M</creatorcontrib><creatorcontrib>Roussel, Eduard</creatorcontrib><creatorcontrib>Jakobsen, Jakob Kristian</creatorcontrib><creatorcontrib>Issa, Allaudin</creatorcontrib><creatorcontrib>Lee, Esther W.C</creatorcontrib><creatorcontrib>Schifano, Nicolo</creatorcontrib><creatorcontrib>Alnajjar, Hussain</creatorcontrib><creatorcontrib>Castiglione, Fabio</creatorcontrib><creatorcontrib>Antonelli, Luca</creatorcontrib><creatorcontrib>Oliveira, Pedro</creatorcontrib><creatorcontrib>Lau, Maurice</creatorcontrib><creatorcontrib>Parnham, Arie</creatorcontrib><creatorcontrib>Albersen, Maarten</creatorcontrib><creatorcontrib>Watkin, Nicholas A</creatorcontrib><creatorcontrib>Muneer, Asif</creatorcontrib><creatorcontrib>Ayres, Ben E</creatorcontrib><creatorcontrib>Brouwer, Oscar R</creatorcontrib><creatorcontrib>Sangar, Vijay</creatorcontrib><title>Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer</title><title>JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY</title><description>PURPOSE: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. METHODS: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed. RESULTS: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value < 0.01) Tumour size was not associated with ILN risk (OR 1.01 95% CI 0.99-1.04, p = 0.17). CONCLUSION: Approximately, one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still have ILN metastases despite being clinically node negative. Therefore, invasive ILN staging should strongly be recommended in T1G2 with LVI + or PNI + but importantly, must be discussed in patients with T1G2 with LVI- or PNI-.</description><issn>0171-5216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjM1KAzEUhbNQsFbf4a4LlSTjdOi6-LNw2X24ZO7Y2PRmyE2qfXsj-AAKBw6H7_BdqYU2g1n31mxu1K3Ih267H-xCXd4up_mQzii-RsyAPMJMOTDVjBECNxISA2aCHOQIE_qSssCUcqPvNXC7xR8JcBoJTlRQWkgabovhM5QD7M2LbWIOkcAje8p36nrCKHT_20u1en7a717XxxqpnondKDN6cla7Xmtn7PbRus22GwbTLdXDn8-ufJXuX_ZvqM9fAQ</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Fankhauser, Christian D</creator><creator>de Vries, Hielke M</creator><creator>Roussel, Eduard</creator><creator>Jakobsen, Jakob Kristian</creator><creator>Issa, Allaudin</creator><creator>Lee, Esther W.C</creator><creator>Schifano, Nicolo</creator><creator>Alnajjar, Hussain</creator><creator>Castiglione, Fabio</creator><creator>Antonelli, Luca</creator><creator>Oliveira, Pedro</creator><creator>Lau, Maurice</creator><creator>Parnham, Arie</creator><creator>Albersen, Maarten</creator><creator>Watkin, Nicholas A</creator><creator>Muneer, Asif</creator><creator>Ayres, Ben E</creator><creator>Brouwer, Oscar R</creator><creator>Sangar, Vijay</creator><general>SPRINGER</general><scope>FZOIL</scope></search><sort><creationdate>202209</creationdate><title>Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer</title><author>Fankhauser, Christian D ; de Vries, Hielke M ; Roussel, Eduard ; Jakobsen, Jakob Kristian ; Issa, Allaudin ; Lee, Esther W.C ; Schifano, Nicolo ; Alnajjar, Hussain ; Castiglione, Fabio ; Antonelli, Luca ; Oliveira, Pedro ; Lau, Maurice ; Parnham, Arie ; Albersen, Maarten ; Watkin, Nicholas A ; Muneer, Asif ; Ayres, Ben E ; Brouwer, Oscar R ; Sangar, Vijay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_20_500_12942_6937713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fankhauser, Christian D</creatorcontrib><creatorcontrib>de Vries, Hielke M</creatorcontrib><creatorcontrib>Roussel, Eduard</creatorcontrib><creatorcontrib>Jakobsen, Jakob Kristian</creatorcontrib><creatorcontrib>Issa, Allaudin</creatorcontrib><creatorcontrib>Lee, Esther W.C</creatorcontrib><creatorcontrib>Schifano, Nicolo</creatorcontrib><creatorcontrib>Alnajjar, Hussain</creatorcontrib><creatorcontrib>Castiglione, Fabio</creatorcontrib><creatorcontrib>Antonelli, Luca</creatorcontrib><creatorcontrib>Oliveira, Pedro</creatorcontrib><creatorcontrib>Lau, Maurice</creatorcontrib><creatorcontrib>Parnham, Arie</creatorcontrib><creatorcontrib>Albersen, Maarten</creatorcontrib><creatorcontrib>Watkin, Nicholas A</creatorcontrib><creatorcontrib>Muneer, Asif</creatorcontrib><creatorcontrib>Ayres, Ben E</creatorcontrib><creatorcontrib>Brouwer, Oscar R</creatorcontrib><creatorcontrib>Sangar, Vijay</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fankhauser, Christian D</au><au>de Vries, Hielke M</au><au>Roussel, Eduard</au><au>Jakobsen, Jakob Kristian</au><au>Issa, Allaudin</au><au>Lee, Esther W.C</au><au>Schifano, Nicolo</au><au>Alnajjar, Hussain</au><au>Castiglione, Fabio</au><au>Antonelli, Luca</au><au>Oliveira, Pedro</au><au>Lau, Maurice</au><au>Parnham, Arie</au><au>Albersen, Maarten</au><au>Watkin, Nicholas A</au><au>Muneer, Asif</au><au>Ayres, Ben E</au><au>Brouwer, Oscar R</au><au>Sangar, Vijay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer</atitle><jtitle>JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY</jtitle><date>2022-09</date><risdate>2022</risdate><volume>148</volume><issue>9</issue><spage>2231</spage><epage>2234</epage><pages>2231-2234</pages><issn>0171-5216</issn><abstract>PURPOSE: To analyse the risk of inguinal lymph node (ILN) metastases in T1G2 penile cancer stratified by lymphovascular invasion (LVI), perineural invasion (PNI) and tumour size. METHODS: Retrospective study of men with localised T1G2 penile cancer with non-palpable lymph nodes and no local recurrence during follow-up at six European institutional high-volume centres was performed. ILN involvement was defined as cancer detected during ultrasound-guided fine-needle aspiration cytology, core needle biopsy, dynamic sentinel lymph node biopsy, ILN dissection or inguinal recurrence during follow-up. Uni- and multivariable logistic regression analyses were performed. RESULTS: In the cohort of 554 men with T1G2 penile cancer, from 6 European institutions, ILN metastases were observed in 46/554 men (8%, 95% confidence interval (CI) 6-11%). Men with both, LVI- and PNI- primary cancers had the lowest risk of ILN involvement (6%) whereas men with LVI + or PNI + showed ILN metastases in 22% and 30%. In multivariable regression, men with LVI + or PNI + had higher odds for ILN metastases compared to men with LVI- and PNI- (OR 3.9, 95% CI 1.6-9.0, p value < 0.01) Tumour size was not associated with ILN risk (OR 1.01 95% CI 0.99-1.04, p = 0.17). CONCLUSION: Approximately, one out of ten men with T1G2 overall and one out of four men with either LVI + or PNI + still have ILN metastases despite being clinically node negative. Therefore, invasive ILN staging should strongly be recommended in T1G2 with LVI + or PNI + but importantly, must be discussed in patients with T1G2 with LVI- or PNI-.</abstract><pub>SPRINGER</pub></addata></record> |
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| title | Lymphovascular and perineural invasion are risk factors for inguinal lymph node metastases in men with T1G2 penile cancer |
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