A non-canonical role for pyruvate kinase M2 as a functional modulator of Ca2+ signalling through IP3 receptors

Pyruvate kinase isoform M2 (PKM2) is a rate-limiting glycolytic enzyme that is widely expressed in embryonic tissues. The expression of PKM2 declines in some tissues following embryogenesis, while other pyruvate kinase isozymes are upregulated. However, PKM2 is highly expressed in cancer cells and i...

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Veröffentlicht in:	BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2022-04, Vol.1869 (4)
Hauptverfasser:	Lavik, Andrew R, McColl, Karen S, Lemos, Fernanda O, Kerkhofs, Martijn, Zhong, Fei, Harr, Michael, Schlatzer, Daniela, Hamada, Kozo, Mikoshiba, Katsuhiko, Crea, Francesco, Bultynck, Geert, Bootman, Martin D, Parys, Jan B, Distelhorst, Clark W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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