Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest
BACKGROUND: In patients with shock after acute myocardial infarction (AMI), the optimal level of pharmacologic support is unknown. Whereas higher doses may increase myocardial oxygen consumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase infarct size. OB...
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| Veröffentlicht in: | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2020-08, Vol.76 (7), p.812-824 |
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| creator | Ameloot, Koen Jakkula, Pekka Haestbacka, Johanna Reinikainen, Matti Pettila, Ville Loisa, Pekka Tiainen, Marjaana Bendel, Stepani Birkelund, Thomas Belmans, Ann Palmers, Pieter-Jan Bogaerts, Eline Lemmens, Robin De Deyne, Cathy Ferdinande, Bert Dupont, Matthias Janssens, Stefan Dens, Joseph Skrifvars, Markus B |
| description | BACKGROUND: In patients with shock after acute myocardial infarction (AMI), the optimal level of pharmacologic support is unknown. Whereas higher doses may increase myocardial oxygen consumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase infarct size. OBJECTIVES: This study aimed to determine the optimal mean arterial pressure (MAP) in patients with AMI and shock after cardiac arrest. METHODS: This study used patient-level pooled analysis of post-cardiac arrest patients with shock after AMI randomized in the Neuroprotect (Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients; NCT02541591) and COMACARE (Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation; NCT02698917) trials who were randomized to MAP 65 mm Hg or MAP 80/85 to 100 mm Hg targets during the first 36 h after admission. The primary endpoint was the area under the 72-h high-sensitivity troponin-T curve. RESULTS: Of 235 patients originally randomized, 120 patients had AMI with shock. Patients assigned to the higher MAP target (n = 58) received higher doses of norepinephrine (p = 0.004) and dobutamine (p = 0.01) and reached higher MAPs (86 ± 9 mm Hg vs. 72 ± 10 mm Hg, p |
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| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_20_500_12942_686731</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20_500_12942_686731</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_20_500_12942_6867313</originalsourceid><addsrcrecordid>eNqVjMuqwjAUALNQ8HH9h7MWlLS9tnZZRdGFWFC4y5CbnmK0JpKciP69In6ArgaGYVqsy7NkMop4nnVYz_sj5zydRnmX_W8vpM_hDLPG2gpKh94Hh6ANlJI0GvLwp-kAu4NVJyhqQgeFCoSwuVslXaVlA2tTS6dIWwPSVDB_aQWFe-7oh7Vr2XgcvNlnw-ViP1-NTqHBcEUjKn-RCkXMxYRzEcX5byzSaZolUdJn449jQTdKvro_AHosVac</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest</title><source>Lirias (KU Leuven Association)</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Ameloot, Koen ; Jakkula, Pekka ; Haestbacka, Johanna ; Reinikainen, Matti ; Pettila, Ville ; Loisa, Pekka ; Tiainen, Marjaana ; Bendel, Stepani ; Birkelund, Thomas ; Belmans, Ann ; Palmers, Pieter-Jan ; Bogaerts, Eline ; Lemmens, Robin ; De Deyne, Cathy ; Ferdinande, Bert ; Dupont, Matthias ; Janssens, Stefan ; Dens, Joseph ; Skrifvars, Markus B</creator><creatorcontrib>Ameloot, Koen ; Jakkula, Pekka ; Haestbacka, Johanna ; Reinikainen, Matti ; Pettila, Ville ; Loisa, Pekka ; Tiainen, Marjaana ; Bendel, Stepani ; Birkelund, Thomas ; Belmans, Ann ; Palmers, Pieter-Jan ; Bogaerts, Eline ; Lemmens, Robin ; De Deyne, Cathy ; Ferdinande, Bert ; Dupont, Matthias ; Janssens, Stefan ; Dens, Joseph ; Skrifvars, Markus B</creatorcontrib><description>BACKGROUND: In patients with shock after acute myocardial infarction (AMI), the optimal level of pharmacologic support is unknown. Whereas higher doses may increase myocardial oxygen consumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase infarct size. OBJECTIVES: This study aimed to determine the optimal mean arterial pressure (MAP) in patients with AMI and shock after cardiac arrest. METHODS: This study used patient-level pooled analysis of post-cardiac arrest patients with shock after AMI randomized in the Neuroprotect (Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients; NCT02541591) and COMACARE (Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation; NCT02698917) trials who were randomized to MAP 65 mm Hg or MAP 80/85 to 100 mm Hg targets during the first 36 h after admission. The primary endpoint was the area under the 72-h high-sensitivity troponin-T curve. RESULTS: Of 235 patients originally randomized, 120 patients had AMI with shock. Patients assigned to the higher MAP target (n = 58) received higher doses of norepinephrine (p = 0.004) and dobutamine (p = 0.01) and reached higher MAPs (86 ± 9 mm Hg vs. 72 ± 10 mm Hg, p < 0.001). Whereas admission hemodynamics and angiographic findings were all well-balanced and revascularization was performed equally effective, the area under the 72-h high-sensitivity troponin-T curve was lower in patients assigned to the higher MAP target (median: 1.14 μg.72 h/l [interquartile range: 0.35 to 2.31 μg.72 h/l] vs. median: 1.56 μg.72 h/l [interquartile range: 0.61 to 4.72 μg. 72 h/l]; p = 0.04). Additional pharmacologic support did not increase the risk of a new cardiac arrest (p = 0.88) or atrial fibrillation (p = 0.94). Survival with good neurologic outcome at 180 days was not different between both groups (64% vs. 53%, odds ratio: 1.55; 95% confidence interval: 0.74 to 3.22). CONCLUSIONS: In post-cardiac arrest patients with shock after AMI, targeting MAP between 80/85 and 100 mm Hg with additional use of inotropes and vasopressors was associated with smaller myocardial injury.</description><identifier>ISSN: 0735-1097</identifier><language>eng</language><publisher>ELSEVIER SCIENCE INC</publisher><ispartof>JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020-08, Vol.76 (7), p.812-824</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,27837</link.rule.ids></links><search><creatorcontrib>Ameloot, Koen</creatorcontrib><creatorcontrib>Jakkula, Pekka</creatorcontrib><creatorcontrib>Haestbacka, Johanna</creatorcontrib><creatorcontrib>Reinikainen, Matti</creatorcontrib><creatorcontrib>Pettila, Ville</creatorcontrib><creatorcontrib>Loisa, Pekka</creatorcontrib><creatorcontrib>Tiainen, Marjaana</creatorcontrib><creatorcontrib>Bendel, Stepani</creatorcontrib><creatorcontrib>Birkelund, Thomas</creatorcontrib><creatorcontrib>Belmans, Ann</creatorcontrib><creatorcontrib>Palmers, Pieter-Jan</creatorcontrib><creatorcontrib>Bogaerts, Eline</creatorcontrib><creatorcontrib>Lemmens, Robin</creatorcontrib><creatorcontrib>De Deyne, Cathy</creatorcontrib><creatorcontrib>Ferdinande, Bert</creatorcontrib><creatorcontrib>Dupont, Matthias</creatorcontrib><creatorcontrib>Janssens, Stefan</creatorcontrib><creatorcontrib>Dens, Joseph</creatorcontrib><creatorcontrib>Skrifvars, Markus B</creatorcontrib><title>Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest</title><title>JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY</title><description>BACKGROUND: In patients with shock after acute myocardial infarction (AMI), the optimal level of pharmacologic support is unknown. Whereas higher doses may increase myocardial oxygen consumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase infarct size. OBJECTIVES: This study aimed to determine the optimal mean arterial pressure (MAP) in patients with AMI and shock after cardiac arrest. METHODS: This study used patient-level pooled analysis of post-cardiac arrest patients with shock after AMI randomized in the Neuroprotect (Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients; NCT02541591) and COMACARE (Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation; NCT02698917) trials who were randomized to MAP 65 mm Hg or MAP 80/85 to 100 mm Hg targets during the first 36 h after admission. The primary endpoint was the area under the 72-h high-sensitivity troponin-T curve. RESULTS: Of 235 patients originally randomized, 120 patients had AMI with shock. Patients assigned to the higher MAP target (n = 58) received higher doses of norepinephrine (p = 0.004) and dobutamine (p = 0.01) and reached higher MAPs (86 ± 9 mm Hg vs. 72 ± 10 mm Hg, p < 0.001). Whereas admission hemodynamics and angiographic findings were all well-balanced and revascularization was performed equally effective, the area under the 72-h high-sensitivity troponin-T curve was lower in patients assigned to the higher MAP target (median: 1.14 μg.72 h/l [interquartile range: 0.35 to 2.31 μg.72 h/l] vs. median: 1.56 μg.72 h/l [interquartile range: 0.61 to 4.72 μg. 72 h/l]; p = 0.04). Additional pharmacologic support did not increase the risk of a new cardiac arrest (p = 0.88) or atrial fibrillation (p = 0.94). Survival with good neurologic outcome at 180 days was not different between both groups (64% vs. 53%, odds ratio: 1.55; 95% confidence interval: 0.74 to 3.22). CONCLUSIONS: In post-cardiac arrest patients with shock after AMI, targeting MAP between 80/85 and 100 mm Hg with additional use of inotropes and vasopressors was associated with smaller myocardial injury.</description><issn>0735-1097</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjMuqwjAUALNQ8HH9h7MWlLS9tnZZRdGFWFC4y5CbnmK0JpKciP69In6ArgaGYVqsy7NkMop4nnVYz_sj5zydRnmX_W8vpM_hDLPG2gpKh94Hh6ANlJI0GvLwp-kAu4NVJyhqQgeFCoSwuVslXaVlA2tTS6dIWwPSVDB_aQWFe-7oh7Vr2XgcvNlnw-ViP1-NTqHBcEUjKn-RCkXMxYRzEcX5byzSaZolUdJn449jQTdKvro_AHosVac</recordid><startdate>20200818</startdate><enddate>20200818</enddate><creator>Ameloot, Koen</creator><creator>Jakkula, Pekka</creator><creator>Haestbacka, Johanna</creator><creator>Reinikainen, Matti</creator><creator>Pettila, Ville</creator><creator>Loisa, Pekka</creator><creator>Tiainen, Marjaana</creator><creator>Bendel, Stepani</creator><creator>Birkelund, Thomas</creator><creator>Belmans, Ann</creator><creator>Palmers, Pieter-Jan</creator><creator>Bogaerts, Eline</creator><creator>Lemmens, Robin</creator><creator>De Deyne, Cathy</creator><creator>Ferdinande, Bert</creator><creator>Dupont, Matthias</creator><creator>Janssens, Stefan</creator><creator>Dens, Joseph</creator><creator>Skrifvars, Markus B</creator><general>ELSEVIER SCIENCE INC</general><scope>FZOIL</scope></search><sort><creationdate>20200818</creationdate><title>Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest</title><author>Ameloot, Koen ; Jakkula, Pekka ; Haestbacka, Johanna ; Reinikainen, Matti ; Pettila, Ville ; Loisa, Pekka ; Tiainen, Marjaana ; Bendel, Stepani ; Birkelund, Thomas ; Belmans, Ann ; Palmers, Pieter-Jan ; Bogaerts, Eline ; Lemmens, Robin ; De Deyne, Cathy ; Ferdinande, Bert ; Dupont, Matthias ; Janssens, Stefan ; Dens, Joseph ; Skrifvars, Markus B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_20_500_12942_6867313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ameloot, Koen</creatorcontrib><creatorcontrib>Jakkula, Pekka</creatorcontrib><creatorcontrib>Haestbacka, Johanna</creatorcontrib><creatorcontrib>Reinikainen, Matti</creatorcontrib><creatorcontrib>Pettila, Ville</creatorcontrib><creatorcontrib>Loisa, Pekka</creatorcontrib><creatorcontrib>Tiainen, Marjaana</creatorcontrib><creatorcontrib>Bendel, Stepani</creatorcontrib><creatorcontrib>Birkelund, Thomas</creatorcontrib><creatorcontrib>Belmans, Ann</creatorcontrib><creatorcontrib>Palmers, Pieter-Jan</creatorcontrib><creatorcontrib>Bogaerts, Eline</creatorcontrib><creatorcontrib>Lemmens, Robin</creatorcontrib><creatorcontrib>De Deyne, Cathy</creatorcontrib><creatorcontrib>Ferdinande, Bert</creatorcontrib><creatorcontrib>Dupont, Matthias</creatorcontrib><creatorcontrib>Janssens, Stefan</creatorcontrib><creatorcontrib>Dens, Joseph</creatorcontrib><creatorcontrib>Skrifvars, Markus B</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ameloot, Koen</au><au>Jakkula, Pekka</au><au>Haestbacka, Johanna</au><au>Reinikainen, Matti</au><au>Pettila, Ville</au><au>Loisa, Pekka</au><au>Tiainen, Marjaana</au><au>Bendel, Stepani</au><au>Birkelund, Thomas</au><au>Belmans, Ann</au><au>Palmers, Pieter-Jan</au><au>Bogaerts, Eline</au><au>Lemmens, Robin</au><au>De Deyne, Cathy</au><au>Ferdinande, Bert</au><au>Dupont, Matthias</au><au>Janssens, Stefan</au><au>Dens, Joseph</au><au>Skrifvars, Markus B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest</atitle><jtitle>JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY</jtitle><date>2020-08-18</date><risdate>2020</risdate><volume>76</volume><issue>7</issue><spage>812</spage><epage>824</epage><pages>812-824</pages><issn>0735-1097</issn><abstract>BACKGROUND: In patients with shock after acute myocardial infarction (AMI), the optimal level of pharmacologic support is unknown. Whereas higher doses may increase myocardial oxygen consumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase infarct size. OBJECTIVES: This study aimed to determine the optimal mean arterial pressure (MAP) in patients with AMI and shock after cardiac arrest. METHODS: This study used patient-level pooled analysis of post-cardiac arrest patients with shock after AMI randomized in the Neuroprotect (Neuroprotective Goal Directed Hemodynamic Optimization in Post-cardiac Arrest Patients; NCT02541591) and COMACARE (Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation; NCT02698917) trials who were randomized to MAP 65 mm Hg or MAP 80/85 to 100 mm Hg targets during the first 36 h after admission. The primary endpoint was the area under the 72-h high-sensitivity troponin-T curve. RESULTS: Of 235 patients originally randomized, 120 patients had AMI with shock. Patients assigned to the higher MAP target (n = 58) received higher doses of norepinephrine (p = 0.004) and dobutamine (p = 0.01) and reached higher MAPs (86 ± 9 mm Hg vs. 72 ± 10 mm Hg, p < 0.001). Whereas admission hemodynamics and angiographic findings were all well-balanced and revascularization was performed equally effective, the area under the 72-h high-sensitivity troponin-T curve was lower in patients assigned to the higher MAP target (median: 1.14 μg.72 h/l [interquartile range: 0.35 to 2.31 μg.72 h/l] vs. median: 1.56 μg.72 h/l [interquartile range: 0.61 to 4.72 μg. 72 h/l]; p = 0.04). Additional pharmacologic support did not increase the risk of a new cardiac arrest (p = 0.88) or atrial fibrillation (p = 0.94). Survival with good neurologic outcome at 180 days was not different between both groups (64% vs. 53%, odds ratio: 1.55; 95% confidence interval: 0.74 to 3.22). CONCLUSIONS: In post-cardiac arrest patients with shock after AMI, targeting MAP between 80/85 and 100 mm Hg with additional use of inotropes and vasopressors was associated with smaller myocardial injury.</abstract><pub>ELSEVIER SCIENCE INC</pub></addata></record> |
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| title | Optimum Blood Pressure in Patients With Shock After Acute Myocardial Infarction and Cardiac Arrest |
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