Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies

Two series of new pyridyl-bearing fused bicyclic analogues designed to target the dual-tolerant regions of the non-nucleoside reverse transcriptase inhibitor (NNRTI)-binding pocket were synthesized and evaluated for their anti-HIV activities. Several compounds, such as 6, 14, 15, 21, 30, and 33, wer...

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Veröffentlicht in:	JOURNAL OF MEDICINAL CHEMISTRY 2021-09, Vol.64 (18), p.13604-13621
Hauptverfasser:	Huang, Boshi, Ginex, Tiziana, Javier Luque, F, Jiang, Xiangyi, Gao, Ping, Zhang, Jian, Kang, Dongwei, Daelemans, Dirk, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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