Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma: Proof of Concept Studies

Glioblastoma (GBM), a highly invasive and vascular malignancy is shown to rapidly develop resistance and evolve to a more invasive phenotype following bevacizumab (Bev) therapy. Rho Guanine Nucleotide Exchange Factor proteins (RhoGEFs) are mediators of key components in Bev resistance pathways, GBM...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	CANCERS 2020-12, Vol.12 (12)
Hauptverfasser:	Connor, Kate, Murray, David W, Jarzabek, Monika A, Tran, Nhan L, White, Kieron, Dicker, Patrick, Sweeney, Kieron J, O'Halloran, Philip J, MacCarthy, Brian, Shiels, Liam P, Lodi, Francesca, Lambrechts, Diether, Sarkaria, Jann N, Schiffelers, Raymond M, Symons, Marc, Byrne, Annette T
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!