Ceramide analog [18F]F-HPA-12 detects sphingolipid disbalance in the brain of Alzheimer's disease transgenic mice by functioning as a metabolic probe

The metabolism of ceramides is deregulated in the brain of Alzheimer's disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β pathology. However, how the ceramide metabolism changes over time in AD, in vivo, remains unknown. Distribution and metabolism of [18F]F-H...

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Veröffentlicht in:	SCIENTIFIC REPORTS 2020-11, Vol.10 (1)
Hauptverfasser:	Crivelli, Simone M, van Kruining, Daan, Luo, Qian, Stevens, Jo A.A, Giovagnoni, Caterina, Paulus, Andreas, Bauwens, Matthias, Berkes, Dusan, de Vries, Helga E, Mulder, Monique T, Walter, Jochen, Waelkens, Etienne, Derua, Rita, Swinnen, Johannes, Dehairs, Jonas, Mottaghy, Felix M, Losen, Mario, Bieberich, Erhard, Martinez-Martinez, Pilar
Format:	Artikel
Sprache:	eng
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