Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus
AIMS: Resting echocardiography is a valuable method for detecting subclinical heart failure (HF) in patients with diabetes mellitus (DM). However, few studies have assessed the incremental value of diastolic stress for detecting subclinical HF in this population. METHODS AND RESULTS: Asymptomatic pa...
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| Veröffentlicht in: | EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING 2020-08, Vol.21 (8), p.876-884 |
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| creator | Nishi, Tomoko Kobayashi, Yukari Christle, Jeffrey W Cauwenberghs, Nicholas Boralkar, Kalyani Moneghetti, Kegan Amsallem, Myriam Hedman, Kristofer Contrepois, Kevin Myers, Jonathan Mahaffey, Kenneth W Schnittger, Ingela Kuznetsova, Tatiana Palaniappan, Latha Haddad, Francois |
| description | AIMS: Resting echocardiography is a valuable method for detecting subclinical heart failure (HF) in patients with diabetes mellitus (DM). However, few studies have assessed the incremental value of diastolic stress for detecting subclinical HF in this population. METHODS AND RESULTS: Asymptomatic patients with Type 2 DM were prospectively enrolled. Subclinical HF was assessed using systolic dysfunction (left ventricular longitudinal strain 10 (beta = -0.17) were independently associated with peak METs (combined R2 = 0.46). A network correlation map revealed the connectivity of peak METs and diastolic properties as central features in patients with DM. CONCLUSION: Diastolic stress test improves the detection of subclinical HF in patients with diabetes mellitus. |
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| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_123456789_657307</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>123456789_657307</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_123456789_6573073</originalsourceid><addsrcrecordid>eNqVzLFuwkAQBNArQAIF_mE7CoRk7LMNNSIifXrrOK9hYTmQd89J_p5Dygck00zzZkZmmme2XuU2sxMzF7lkKaWtbL6emuEj-B5vGNQxDI4jwr2DlpzoncmDaI8ioCgKFIDaJKn7oXACiUfPFMin5Rldr9A54tjjCz6cUqICX6Tn198R0wfckJk0ysyMO8eC899-M4v3_efusLpGxjhgaFp5OI_NOi9sWdWbbVOVdZHVxX_k8m-y0W8tnjjQXOA</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus</title><source>Lirias (KU Leuven Association)</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Nishi, Tomoko ; Kobayashi, Yukari ; Christle, Jeffrey W ; Cauwenberghs, Nicholas ; Boralkar, Kalyani ; Moneghetti, Kegan ; Amsallem, Myriam ; Hedman, Kristofer ; Contrepois, Kevin ; Myers, Jonathan ; Mahaffey, Kenneth W ; Schnittger, Ingela ; Kuznetsova, Tatiana ; Palaniappan, Latha ; Haddad, Francois</creator><creatorcontrib>Nishi, Tomoko ; Kobayashi, Yukari ; Christle, Jeffrey W ; Cauwenberghs, Nicholas ; Boralkar, Kalyani ; Moneghetti, Kegan ; Amsallem, Myriam ; Hedman, Kristofer ; Contrepois, Kevin ; Myers, Jonathan ; Mahaffey, Kenneth W ; Schnittger, Ingela ; Kuznetsova, Tatiana ; Palaniappan, Latha ; Haddad, Francois</creatorcontrib><description>AIMS: Resting echocardiography is a valuable method for detecting subclinical heart failure (HF) in patients with diabetes mellitus (DM). However, few studies have assessed the incremental value of diastolic stress for detecting subclinical HF in this population. METHODS AND RESULTS: Asymptomatic patients with Type 2 DM were prospectively enrolled. Subclinical HF was assessed using systolic dysfunction (left ventricular longitudinal strain <16% at rest and <19% after exercise in absolute value), abnormal cardiac morphology, or diastolic dysfunction (E/e' > 10). Metabolic equivalents (METs) were calculated using treadmill speed and grade, and functional capacity was assessed by percent-predicted METs (ppMETs). Among 161 patients studied (mean age of 59 ± 11 years and 57% male sex), subclinical HF was observed in 68% at rest and in 79% with exercise. Among characteristics, diastolic stress had the highest yield in improving detection of HF with 57% of abnormal cases after exercise and 45% at rest. Patients with revealed diastolic dysfunction during stress had significantly lower exercise capacity than patients with normal diastolic stress (7.3 ± 2.1 vs. 8.8 ± 2.5, P < 0.001 for peak METs and 91 ± 30% vs. 105 ± 30%, P = 0.04 for ppMETs). On multivariable modelling found that age (beta = -0.33), male sex (beta = 0.21), body mass index (beta = -0.49), and exercise E/e' >10 (beta = -0.17) were independently associated with peak METs (combined R2 = 0.46). A network correlation map revealed the connectivity of peak METs and diastolic properties as central features in patients with DM. CONCLUSION: Diastolic stress test improves the detection of subclinical HF in patients with diabetes mellitus.</description><identifier>ISSN: 2047-2404</identifier><language>eng</language><publisher>OXFORD UNIV PRESS</publisher><ispartof>EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING, 2020-08, Vol.21 (8), p.876-884</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,778,782,27843</link.rule.ids></links><search><creatorcontrib>Nishi, Tomoko</creatorcontrib><creatorcontrib>Kobayashi, Yukari</creatorcontrib><creatorcontrib>Christle, Jeffrey W</creatorcontrib><creatorcontrib>Cauwenberghs, Nicholas</creatorcontrib><creatorcontrib>Boralkar, Kalyani</creatorcontrib><creatorcontrib>Moneghetti, Kegan</creatorcontrib><creatorcontrib>Amsallem, Myriam</creatorcontrib><creatorcontrib>Hedman, Kristofer</creatorcontrib><creatorcontrib>Contrepois, Kevin</creatorcontrib><creatorcontrib>Myers, Jonathan</creatorcontrib><creatorcontrib>Mahaffey, Kenneth W</creatorcontrib><creatorcontrib>Schnittger, Ingela</creatorcontrib><creatorcontrib>Kuznetsova, Tatiana</creatorcontrib><creatorcontrib>Palaniappan, Latha</creatorcontrib><creatorcontrib>Haddad, Francois</creatorcontrib><title>Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus</title><title>EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING</title><description>AIMS: Resting echocardiography is a valuable method for detecting subclinical heart failure (HF) in patients with diabetes mellitus (DM). However, few studies have assessed the incremental value of diastolic stress for detecting subclinical HF in this population. METHODS AND RESULTS: Asymptomatic patients with Type 2 DM were prospectively enrolled. Subclinical HF was assessed using systolic dysfunction (left ventricular longitudinal strain <16% at rest and <19% after exercise in absolute value), abnormal cardiac morphology, or diastolic dysfunction (E/e' > 10). Metabolic equivalents (METs) were calculated using treadmill speed and grade, and functional capacity was assessed by percent-predicted METs (ppMETs). Among 161 patients studied (mean age of 59 ± 11 years and 57% male sex), subclinical HF was observed in 68% at rest and in 79% with exercise. Among characteristics, diastolic stress had the highest yield in improving detection of HF with 57% of abnormal cases after exercise and 45% at rest. Patients with revealed diastolic dysfunction during stress had significantly lower exercise capacity than patients with normal diastolic stress (7.3 ± 2.1 vs. 8.8 ± 2.5, P < 0.001 for peak METs and 91 ± 30% vs. 105 ± 30%, P = 0.04 for ppMETs). On multivariable modelling found that age (beta = -0.33), male sex (beta = 0.21), body mass index (beta = -0.49), and exercise E/e' >10 (beta = -0.17) were independently associated with peak METs (combined R2 = 0.46). A network correlation map revealed the connectivity of peak METs and diastolic properties as central features in patients with DM. CONCLUSION: Diastolic stress test improves the detection of subclinical HF in patients with diabetes mellitus.</description><issn>2047-2404</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVzLFuwkAQBNArQAIF_mE7CoRk7LMNNSIifXrrOK9hYTmQd89J_p5Dygck00zzZkZmmme2XuU2sxMzF7lkKaWtbL6emuEj-B5vGNQxDI4jwr2DlpzoncmDaI8ioCgKFIDaJKn7oXACiUfPFMin5Rldr9A54tjjCz6cUqICX6Tn198R0wfckJk0ysyMO8eC899-M4v3_efusLpGxjhgaFp5OI_NOi9sWdWbbVOVdZHVxX_k8m-y0W8tnjjQXOA</recordid><startdate>202008</startdate><enddate>202008</enddate><creator>Nishi, Tomoko</creator><creator>Kobayashi, Yukari</creator><creator>Christle, Jeffrey W</creator><creator>Cauwenberghs, Nicholas</creator><creator>Boralkar, Kalyani</creator><creator>Moneghetti, Kegan</creator><creator>Amsallem, Myriam</creator><creator>Hedman, Kristofer</creator><creator>Contrepois, Kevin</creator><creator>Myers, Jonathan</creator><creator>Mahaffey, Kenneth W</creator><creator>Schnittger, Ingela</creator><creator>Kuznetsova, Tatiana</creator><creator>Palaniappan, Latha</creator><creator>Haddad, Francois</creator><general>OXFORD UNIV PRESS</general><scope>FZOIL</scope></search><sort><creationdate>202008</creationdate><title>Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus</title><author>Nishi, Tomoko ; Kobayashi, Yukari ; Christle, Jeffrey W ; Cauwenberghs, Nicholas ; Boralkar, Kalyani ; Moneghetti, Kegan ; Amsallem, Myriam ; Hedman, Kristofer ; Contrepois, Kevin ; Myers, Jonathan ; Mahaffey, Kenneth W ; Schnittger, Ingela ; Kuznetsova, Tatiana ; Palaniappan, Latha ; Haddad, Francois</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_123456789_6573073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishi, Tomoko</creatorcontrib><creatorcontrib>Kobayashi, Yukari</creatorcontrib><creatorcontrib>Christle, Jeffrey W</creatorcontrib><creatorcontrib>Cauwenberghs, Nicholas</creatorcontrib><creatorcontrib>Boralkar, Kalyani</creatorcontrib><creatorcontrib>Moneghetti, Kegan</creatorcontrib><creatorcontrib>Amsallem, Myriam</creatorcontrib><creatorcontrib>Hedman, Kristofer</creatorcontrib><creatorcontrib>Contrepois, Kevin</creatorcontrib><creatorcontrib>Myers, Jonathan</creatorcontrib><creatorcontrib>Mahaffey, Kenneth W</creatorcontrib><creatorcontrib>Schnittger, Ingela</creatorcontrib><creatorcontrib>Kuznetsova, Tatiana</creatorcontrib><creatorcontrib>Palaniappan, Latha</creatorcontrib><creatorcontrib>Haddad, Francois</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishi, Tomoko</au><au>Kobayashi, Yukari</au><au>Christle, Jeffrey W</au><au>Cauwenberghs, Nicholas</au><au>Boralkar, Kalyani</au><au>Moneghetti, Kegan</au><au>Amsallem, Myriam</au><au>Hedman, Kristofer</au><au>Contrepois, Kevin</au><au>Myers, Jonathan</au><au>Mahaffey, Kenneth W</au><au>Schnittger, Ingela</au><au>Kuznetsova, Tatiana</au><au>Palaniappan, Latha</au><au>Haddad, Francois</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus</atitle><jtitle>EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING</jtitle><date>2020-08</date><risdate>2020</risdate><volume>21</volume><issue>8</issue><spage>876</spage><epage>884</epage><pages>876-884</pages><issn>2047-2404</issn><abstract>AIMS: Resting echocardiography is a valuable method for detecting subclinical heart failure (HF) in patients with diabetes mellitus (DM). However, few studies have assessed the incremental value of diastolic stress for detecting subclinical HF in this population. METHODS AND RESULTS: Asymptomatic patients with Type 2 DM were prospectively enrolled. Subclinical HF was assessed using systolic dysfunction (left ventricular longitudinal strain <16% at rest and <19% after exercise in absolute value), abnormal cardiac morphology, or diastolic dysfunction (E/e' > 10). Metabolic equivalents (METs) were calculated using treadmill speed and grade, and functional capacity was assessed by percent-predicted METs (ppMETs). Among 161 patients studied (mean age of 59 ± 11 years and 57% male sex), subclinical HF was observed in 68% at rest and in 79% with exercise. Among characteristics, diastolic stress had the highest yield in improving detection of HF with 57% of abnormal cases after exercise and 45% at rest. Patients with revealed diastolic dysfunction during stress had significantly lower exercise capacity than patients with normal diastolic stress (7.3 ± 2.1 vs. 8.8 ± 2.5, P < 0.001 for peak METs and 91 ± 30% vs. 105 ± 30%, P = 0.04 for ppMETs). On multivariable modelling found that age (beta = -0.33), male sex (beta = 0.21), body mass index (beta = -0.49), and exercise E/e' >10 (beta = -0.17) were independently associated with peak METs (combined R2 = 0.46). A network correlation map revealed the connectivity of peak METs and diastolic properties as central features in patients with DM. CONCLUSION: Diastolic stress test improves the detection of subclinical HF in patients with diabetes mellitus.</abstract><pub>OXFORD UNIV PRESS</pub><oa>free_for_read</oa></addata></record> |
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| source | Lirias (KU Leuven Association); Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| title | Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus |
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