α-Synuclein toxicity in yeast and human cells is caused by cell cycle re-entry and autophagy degradation of ribonucleotide reductase 1

α-Synuclein (aSyn) toxicity is associated with cell cycle alterations, activation of DNA damage responses (DDR), and deregulation of autophagy. However, the relationships between these phenomena remain largely unknown. Here, we demonstrate that in a yeast model of aSyn toxicity and aging, aSyn expre...

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Veröffentlicht in:	AGING CELL 2019-08, Vol.18 (4)
Hauptverfasser:	Sampaio-Marques, Belem, Guedes, Ana, Vasilevskiy, Igor, Goncalves, Susana, Outeiro, Tiago F, Winderickx, Joris, Burhans, William C, Ludovico, Paula
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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