Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women
An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway t...
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| Veröffentlicht in: | CANCER MEDICINE 2019-05, Vol.8 (5), p.2503-2513 |
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| creator | Grant, Delores J Manichaikul, Ani Alberg, Anthony J Bandera, Elisa Barnholtz-Sloan, Jill Bondy, Melissa Cote, Michele L Funkhouser, Ellen Moorman, Patricia G Peres, Lauren C Peters, Edward S Schwartz, Ann G Terry, Paul D Wang, Xin-Qun Keku, Temitope O Hoyo, Cathrine Berchuck, Andrew Sandler, Dale P Taylor, Jack A O'Brien, Katie M Edwards, Digna R. Velez Edwards, Todd L Beeghly-Fadiel, Alicia Wentzensen, Nicolas Pearce, Celeste Leigh Wu, Anna H Whittemore, Alice S McGuire, Valerie Sieh, Weiva Rothstein, Joseph H Modugno, Francesmary Ness, Roberta Moysich, Kirsten Rossing, Mary Anne Doherty, Jennifer A Sellers, Thomas A Permuth-Way, Jennifer B Monteiro, Alvaro N Levine, Douglas A Setiawan, Veronica Wendy Haiman, Christopher A LeMarchand, Loic Wilkens, Lynne R Karlan, Beth Y Menon, Usha Ramus, Susan Gayther, Simon Gentry-Maharaj, Aleksandra Terry, Kathryn L Cramer, Daniel W Goode, Ellen L Larson, Melissa C Kaufmann, Scott H Cannioto, Rikki Odunsi, Kunle Etter, John L Huang, Ruea-Yea Bernardini, Marcus Q Tone, Alicia A May, Taymaa Goodman, Marc T Thompson, Pamela J Carney, Michael E Tworoger, Shelley S Poole, Elizabeth M Lambrechts, Diether Vergote, Ignace Vanderstichele, Adriaan Van Nieuwenhuysen, Els Anton-Culver, Hoda Ziogas, Argyrios Brenton, James D Bjorge, Line Salvensen, Helga B Kiemeney, Lambertus A Massuger, Leon F.A.G Pejovic, Tanja Bruegl, Amanda Moffitt, Melissa Cook, Linda Le, Nhu D Brooks-Wilson, Angela Kelemen, Linda E Pharoah, Paul D.P Song, Honglin Campbell, Ian Eccles, Diana DeFazio, Anna Kennedy, Catherine J Schildkraut, Joellen M |
| description | An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10-6 , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10-5 , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10-5 , BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC. |
| format | Article |
| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_123456789_636794</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>123456789_636794</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_123456789_6367943</originalsourceid><addsrcrecordid>eNqVjb1Ow0AQhC0EEhHkHbajQBH-i01KC5xQoyBKa7HX8cL5zro9O_iReEtOQEEJW8zOSJ9mToJFHKbrVZ4l6ekvfx4sRV5Df3kYZ3m0CD7KCdWIjo0G08LEDnvWcA8vbGTWriNhAdQNDOi6I87g0B7IwYE0CViaCJXA024fF9FN_EWWu-0jDEbNvbFDx9L7AhFTMzpq4MiuAxq8kmJUYCa0jBpq1DVZ8ONFa9knKHr6Ns-mJ30ZnLV-ipY__yK42pb7u4fV26honEhXjQxYUxXFSbrO8ttNlSVZvkmT_5DXfyMr9-6ST92_b8g</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women</title><source>Wiley Online Library - AutoHoldings Journals</source><source>Lirias (KU Leuven Association)</source><source>Wiley Online Library Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>EZB Electronic Journals Library</source><creator>Grant, Delores J ; Manichaikul, Ani ; Alberg, Anthony J ; Bandera, Elisa ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L ; Funkhouser, Ellen ; Moorman, Patricia G ; Peres, Lauren C ; Peters, Edward S ; Schwartz, Ann G ; Terry, Paul D ; Wang, Xin-Qun ; Keku, Temitope O ; Hoyo, Cathrine ; Berchuck, Andrew ; Sandler, Dale P ; Taylor, Jack A ; O'Brien, Katie M ; Edwards, Digna R. Velez ; Edwards, Todd L ; Beeghly-Fadiel, Alicia ; Wentzensen, Nicolas ; Pearce, Celeste Leigh ; Wu, Anna H ; Whittemore, Alice S ; McGuire, Valerie ; Sieh, Weiva ; Rothstein, Joseph H ; Modugno, Francesmary ; Ness, Roberta ; Moysich, Kirsten ; Rossing, Mary Anne ; Doherty, Jennifer A ; Sellers, Thomas A ; Permuth-Way, Jennifer B ; Monteiro, Alvaro N ; Levine, Douglas A ; Setiawan, Veronica Wendy ; Haiman, Christopher A ; LeMarchand, Loic ; Wilkens, Lynne R ; Karlan, Beth Y ; Menon, Usha ; Ramus, Susan ; Gayther, Simon ; Gentry-Maharaj, Aleksandra ; Terry, Kathryn L ; Cramer, Daniel W ; Goode, Ellen L ; Larson, Melissa C ; Kaufmann, Scott H ; Cannioto, Rikki ; Odunsi, Kunle ; Etter, John L ; Huang, Ruea-Yea ; Bernardini, Marcus Q ; Tone, Alicia A ; May, Taymaa ; Goodman, Marc T ; Thompson, Pamela J ; Carney, Michael E ; Tworoger, Shelley S ; Poole, Elizabeth M ; Lambrechts, Diether ; Vergote, Ignace ; Vanderstichele, Adriaan ; Van Nieuwenhuysen, Els ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Brenton, James D ; Bjorge, Line ; Salvensen, Helga B ; Kiemeney, Lambertus A ; Massuger, Leon F.A.G ; Pejovic, Tanja ; Bruegl, Amanda ; Moffitt, Melissa ; Cook, Linda ; Le, Nhu D ; Brooks-Wilson, Angela ; Kelemen, Linda E ; Pharoah, Paul D.P ; Song, Honglin ; Campbell, Ian ; Eccles, Diana ; DeFazio, Anna ; Kennedy, Catherine J ; Schildkraut, Joellen M</creator><creatorcontrib>Grant, Delores J ; Manichaikul, Ani ; Alberg, Anthony J ; Bandera, Elisa ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L ; Funkhouser, Ellen ; Moorman, Patricia G ; Peres, Lauren C ; Peters, Edward S ; Schwartz, Ann G ; Terry, Paul D ; Wang, Xin-Qun ; Keku, Temitope O ; Hoyo, Cathrine ; Berchuck, Andrew ; Sandler, Dale P ; Taylor, Jack A ; O'Brien, Katie M ; Edwards, Digna R. Velez ; Edwards, Todd L ; Beeghly-Fadiel, Alicia ; Wentzensen, Nicolas ; Pearce, Celeste Leigh ; Wu, Anna H ; Whittemore, Alice S ; McGuire, Valerie ; Sieh, Weiva ; Rothstein, Joseph H ; Modugno, Francesmary ; Ness, Roberta ; Moysich, Kirsten ; Rossing, Mary Anne ; Doherty, Jennifer A ; Sellers, Thomas A ; Permuth-Way, Jennifer B ; Monteiro, Alvaro N ; Levine, Douglas A ; Setiawan, Veronica Wendy ; Haiman, Christopher A ; LeMarchand, Loic ; Wilkens, Lynne R ; Karlan, Beth Y ; Menon, Usha ; Ramus, Susan ; Gayther, Simon ; Gentry-Maharaj, Aleksandra ; Terry, Kathryn L ; Cramer, Daniel W ; Goode, Ellen L ; Larson, Melissa C ; Kaufmann, Scott H ; Cannioto, Rikki ; Odunsi, Kunle ; Etter, John L ; Huang, Ruea-Yea ; Bernardini, Marcus Q ; Tone, Alicia A ; May, Taymaa ; Goodman, Marc T ; Thompson, Pamela J ; Carney, Michael E ; Tworoger, Shelley S ; Poole, Elizabeth M ; Lambrechts, Diether ; Vergote, Ignace ; Vanderstichele, Adriaan ; Van Nieuwenhuysen, Els ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Brenton, James D ; Bjorge, Line ; Salvensen, Helga B ; Kiemeney, Lambertus A ; Massuger, Leon F.A.G ; Pejovic, Tanja ; Bruegl, Amanda ; Moffitt, Melissa ; Cook, Linda ; Le, Nhu D ; Brooks-Wilson, Angela ; Kelemen, Linda E ; Pharoah, Paul D.P ; Song, Honglin ; Campbell, Ian ; Eccles, Diana ; DeFazio, Anna ; Kennedy, Catherine J ; Schildkraut, Joellen M</creatorcontrib><description>An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10-6 , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10-5 , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10-5 , BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC.</description><identifier>ISSN: 2045-7634</identifier><identifier>EISSN: 2045-7634</identifier><language>eng</language><publisher>WILEY</publisher><ispartof>CANCER MEDICINE, 2019-05, Vol.8 (5), p.2503-2513</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,27837</link.rule.ids></links><search><creatorcontrib>Grant, Delores J</creatorcontrib><creatorcontrib>Manichaikul, Ani</creatorcontrib><creatorcontrib>Alberg, Anthony J</creatorcontrib><creatorcontrib>Bandera, Elisa</creatorcontrib><creatorcontrib>Barnholtz-Sloan, Jill</creatorcontrib><creatorcontrib>Bondy, Melissa</creatorcontrib><creatorcontrib>Cote, Michele L</creatorcontrib><creatorcontrib>Funkhouser, Ellen</creatorcontrib><creatorcontrib>Moorman, Patricia G</creatorcontrib><creatorcontrib>Peres, Lauren C</creatorcontrib><creatorcontrib>Peters, Edward S</creatorcontrib><creatorcontrib>Schwartz, Ann G</creatorcontrib><creatorcontrib>Terry, Paul D</creatorcontrib><creatorcontrib>Wang, Xin-Qun</creatorcontrib><creatorcontrib>Keku, Temitope O</creatorcontrib><creatorcontrib>Hoyo, Cathrine</creatorcontrib><creatorcontrib>Berchuck, Andrew</creatorcontrib><creatorcontrib>Sandler, Dale P</creatorcontrib><creatorcontrib>Taylor, Jack A</creatorcontrib><creatorcontrib>O'Brien, Katie M</creatorcontrib><creatorcontrib>Edwards, Digna R. Velez</creatorcontrib><creatorcontrib>Edwards, Todd L</creatorcontrib><creatorcontrib>Beeghly-Fadiel, Alicia</creatorcontrib><creatorcontrib>Wentzensen, Nicolas</creatorcontrib><creatorcontrib>Pearce, Celeste Leigh</creatorcontrib><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Whittemore, Alice S</creatorcontrib><creatorcontrib>McGuire, Valerie</creatorcontrib><creatorcontrib>Sieh, Weiva</creatorcontrib><creatorcontrib>Rothstein, Joseph H</creatorcontrib><creatorcontrib>Modugno, Francesmary</creatorcontrib><creatorcontrib>Ness, Roberta</creatorcontrib><creatorcontrib>Moysich, Kirsten</creatorcontrib><creatorcontrib>Rossing, Mary Anne</creatorcontrib><creatorcontrib>Doherty, Jennifer A</creatorcontrib><creatorcontrib>Sellers, Thomas A</creatorcontrib><creatorcontrib>Permuth-Way, Jennifer B</creatorcontrib><creatorcontrib>Monteiro, Alvaro N</creatorcontrib><creatorcontrib>Levine, Douglas A</creatorcontrib><creatorcontrib>Setiawan, Veronica Wendy</creatorcontrib><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>LeMarchand, Loic</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Karlan, Beth Y</creatorcontrib><creatorcontrib>Menon, Usha</creatorcontrib><creatorcontrib>Ramus, Susan</creatorcontrib><creatorcontrib>Gayther, Simon</creatorcontrib><creatorcontrib>Gentry-Maharaj, Aleksandra</creatorcontrib><creatorcontrib>Terry, Kathryn L</creatorcontrib><creatorcontrib>Cramer, Daniel W</creatorcontrib><creatorcontrib>Goode, Ellen L</creatorcontrib><creatorcontrib>Larson, Melissa C</creatorcontrib><creatorcontrib>Kaufmann, Scott H</creatorcontrib><creatorcontrib>Cannioto, Rikki</creatorcontrib><creatorcontrib>Odunsi, Kunle</creatorcontrib><creatorcontrib>Etter, John L</creatorcontrib><creatorcontrib>Huang, Ruea-Yea</creatorcontrib><creatorcontrib>Bernardini, Marcus Q</creatorcontrib><creatorcontrib>Tone, Alicia A</creatorcontrib><creatorcontrib>May, Taymaa</creatorcontrib><creatorcontrib>Goodman, Marc T</creatorcontrib><creatorcontrib>Thompson, Pamela J</creatorcontrib><creatorcontrib>Carney, Michael E</creatorcontrib><creatorcontrib>Tworoger, Shelley S</creatorcontrib><creatorcontrib>Poole, Elizabeth M</creatorcontrib><creatorcontrib>Lambrechts, Diether</creatorcontrib><creatorcontrib>Vergote, Ignace</creatorcontrib><creatorcontrib>Vanderstichele, Adriaan</creatorcontrib><creatorcontrib>Van Nieuwenhuysen, Els</creatorcontrib><creatorcontrib>Anton-Culver, Hoda</creatorcontrib><creatorcontrib>Ziogas, Argyrios</creatorcontrib><creatorcontrib>Brenton, James D</creatorcontrib><creatorcontrib>Bjorge, Line</creatorcontrib><creatorcontrib>Salvensen, Helga B</creatorcontrib><creatorcontrib>Kiemeney, Lambertus A</creatorcontrib><creatorcontrib>Massuger, Leon F.A.G</creatorcontrib><creatorcontrib>Pejovic, Tanja</creatorcontrib><creatorcontrib>Bruegl, Amanda</creatorcontrib><creatorcontrib>Moffitt, Melissa</creatorcontrib><creatorcontrib>Cook, Linda</creatorcontrib><creatorcontrib>Le, Nhu D</creatorcontrib><creatorcontrib>Brooks-Wilson, Angela</creatorcontrib><creatorcontrib>Kelemen, Linda E</creatorcontrib><creatorcontrib>Pharoah, Paul D.P</creatorcontrib><creatorcontrib>Song, Honglin</creatorcontrib><creatorcontrib>Campbell, Ian</creatorcontrib><creatorcontrib>Eccles, Diana</creatorcontrib><creatorcontrib>DeFazio, Anna</creatorcontrib><creatorcontrib>Kennedy, Catherine J</creatorcontrib><creatorcontrib>Schildkraut, Joellen M</creatorcontrib><title>Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women</title><title>CANCER MEDICINE</title><description>An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10-6 , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10-5 , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10-5 , BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC.</description><issn>2045-7634</issn><issn>2045-7634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVjb1Ow0AQhC0EEhHkHbajQBH-i01KC5xQoyBKa7HX8cL5zro9O_iReEtOQEEJW8zOSJ9mToJFHKbrVZ4l6ekvfx4sRV5Df3kYZ3m0CD7KCdWIjo0G08LEDnvWcA8vbGTWriNhAdQNDOi6I87g0B7IwYE0CViaCJXA024fF9FN_EWWu-0jDEbNvbFDx9L7AhFTMzpq4MiuAxq8kmJUYCa0jBpq1DVZ8ONFa9knKHr6Ns-mJ30ZnLV-ipY__yK42pb7u4fV26honEhXjQxYUxXFSbrO8ttNlSVZvkmT_5DXfyMr9-6ST92_b8g</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Grant, Delores J</creator><creator>Manichaikul, Ani</creator><creator>Alberg, Anthony J</creator><creator>Bandera, Elisa</creator><creator>Barnholtz-Sloan, Jill</creator><creator>Bondy, Melissa</creator><creator>Cote, Michele L</creator><creator>Funkhouser, Ellen</creator><creator>Moorman, Patricia G</creator><creator>Peres, Lauren C</creator><creator>Peters, Edward S</creator><creator>Schwartz, Ann G</creator><creator>Terry, Paul D</creator><creator>Wang, Xin-Qun</creator><creator>Keku, Temitope O</creator><creator>Hoyo, Cathrine</creator><creator>Berchuck, Andrew</creator><creator>Sandler, Dale P</creator><creator>Taylor, Jack A</creator><creator>O'Brien, Katie M</creator><creator>Edwards, Digna R. Velez</creator><creator>Edwards, Todd L</creator><creator>Beeghly-Fadiel, Alicia</creator><creator>Wentzensen, Nicolas</creator><creator>Pearce, Celeste Leigh</creator><creator>Wu, Anna H</creator><creator>Whittemore, Alice S</creator><creator>McGuire, Valerie</creator><creator>Sieh, Weiva</creator><creator>Rothstein, Joseph H</creator><creator>Modugno, Francesmary</creator><creator>Ness, Roberta</creator><creator>Moysich, Kirsten</creator><creator>Rossing, Mary Anne</creator><creator>Doherty, Jennifer A</creator><creator>Sellers, Thomas A</creator><creator>Permuth-Way, Jennifer B</creator><creator>Monteiro, Alvaro N</creator><creator>Levine, Douglas A</creator><creator>Setiawan, Veronica Wendy</creator><creator>Haiman, Christopher A</creator><creator>LeMarchand, Loic</creator><creator>Wilkens, Lynne R</creator><creator>Karlan, Beth Y</creator><creator>Menon, Usha</creator><creator>Ramus, Susan</creator><creator>Gayther, Simon</creator><creator>Gentry-Maharaj, Aleksandra</creator><creator>Terry, Kathryn L</creator><creator>Cramer, Daniel W</creator><creator>Goode, Ellen L</creator><creator>Larson, Melissa C</creator><creator>Kaufmann, Scott H</creator><creator>Cannioto, Rikki</creator><creator>Odunsi, Kunle</creator><creator>Etter, John L</creator><creator>Huang, Ruea-Yea</creator><creator>Bernardini, Marcus Q</creator><creator>Tone, Alicia A</creator><creator>May, Taymaa</creator><creator>Goodman, Marc T</creator><creator>Thompson, Pamela J</creator><creator>Carney, Michael E</creator><creator>Tworoger, Shelley S</creator><creator>Poole, Elizabeth M</creator><creator>Lambrechts, Diether</creator><creator>Vergote, Ignace</creator><creator>Vanderstichele, Adriaan</creator><creator>Van Nieuwenhuysen, Els</creator><creator>Anton-Culver, Hoda</creator><creator>Ziogas, Argyrios</creator><creator>Brenton, James D</creator><creator>Bjorge, Line</creator><creator>Salvensen, Helga B</creator><creator>Kiemeney, Lambertus A</creator><creator>Massuger, Leon F.A.G</creator><creator>Pejovic, Tanja</creator><creator>Bruegl, Amanda</creator><creator>Moffitt, Melissa</creator><creator>Cook, Linda</creator><creator>Le, Nhu D</creator><creator>Brooks-Wilson, Angela</creator><creator>Kelemen, Linda E</creator><creator>Pharoah, Paul D.P</creator><creator>Song, Honglin</creator><creator>Campbell, Ian</creator><creator>Eccles, Diana</creator><creator>DeFazio, Anna</creator><creator>Kennedy, Catherine J</creator><creator>Schildkraut, Joellen M</creator><general>WILEY</general><scope>FZOIL</scope></search><sort><creationdate>201905</creationdate><title>Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women</title><author>Grant, Delores J ; Manichaikul, Ani ; Alberg, Anthony J ; Bandera, Elisa ; Barnholtz-Sloan, Jill ; Bondy, Melissa ; Cote, Michele L ; Funkhouser, Ellen ; Moorman, Patricia G ; Peres, Lauren C ; Peters, Edward S ; Schwartz, Ann G ; Terry, Paul D ; Wang, Xin-Qun ; Keku, Temitope O ; Hoyo, Cathrine ; Berchuck, Andrew ; Sandler, Dale P ; Taylor, Jack A ; O'Brien, Katie M ; Edwards, Digna R. Velez ; Edwards, Todd L ; Beeghly-Fadiel, Alicia ; Wentzensen, Nicolas ; Pearce, Celeste Leigh ; Wu, Anna H ; Whittemore, Alice S ; McGuire, Valerie ; Sieh, Weiva ; Rothstein, Joseph H ; Modugno, Francesmary ; Ness, Roberta ; Moysich, Kirsten ; Rossing, Mary Anne ; Doherty, Jennifer A ; Sellers, Thomas A ; Permuth-Way, Jennifer B ; Monteiro, Alvaro N ; Levine, Douglas A ; Setiawan, Veronica Wendy ; Haiman, Christopher A ; LeMarchand, Loic ; Wilkens, Lynne R ; Karlan, Beth Y ; Menon, Usha ; Ramus, Susan ; Gayther, Simon ; Gentry-Maharaj, Aleksandra ; Terry, Kathryn L ; Cramer, Daniel W ; Goode, Ellen L ; Larson, Melissa C ; Kaufmann, Scott H ; Cannioto, Rikki ; Odunsi, Kunle ; Etter, John L ; Huang, Ruea-Yea ; Bernardini, Marcus Q ; Tone, Alicia A ; May, Taymaa ; Goodman, Marc T ; Thompson, Pamela J ; Carney, Michael E ; Tworoger, Shelley S ; Poole, Elizabeth M ; Lambrechts, Diether ; Vergote, Ignace ; Vanderstichele, Adriaan ; Van Nieuwenhuysen, Els ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Brenton, James D ; Bjorge, Line ; Salvensen, Helga B ; Kiemeney, Lambertus A ; Massuger, Leon F.A.G ; Pejovic, Tanja ; Bruegl, Amanda ; Moffitt, Melissa ; Cook, Linda ; Le, Nhu D ; Brooks-Wilson, Angela ; Kelemen, Linda E ; Pharoah, Paul D.P ; Song, Honglin ; Campbell, Ian ; Eccles, Diana ; DeFazio, Anna ; Kennedy, Catherine J ; Schildkraut, Joellen M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_123456789_6367943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grant, Delores J</creatorcontrib><creatorcontrib>Manichaikul, Ani</creatorcontrib><creatorcontrib>Alberg, Anthony J</creatorcontrib><creatorcontrib>Bandera, Elisa</creatorcontrib><creatorcontrib>Barnholtz-Sloan, Jill</creatorcontrib><creatorcontrib>Bondy, Melissa</creatorcontrib><creatorcontrib>Cote, Michele L</creatorcontrib><creatorcontrib>Funkhouser, Ellen</creatorcontrib><creatorcontrib>Moorman, Patricia G</creatorcontrib><creatorcontrib>Peres, Lauren C</creatorcontrib><creatorcontrib>Peters, Edward S</creatorcontrib><creatorcontrib>Schwartz, Ann G</creatorcontrib><creatorcontrib>Terry, Paul D</creatorcontrib><creatorcontrib>Wang, Xin-Qun</creatorcontrib><creatorcontrib>Keku, Temitope O</creatorcontrib><creatorcontrib>Hoyo, Cathrine</creatorcontrib><creatorcontrib>Berchuck, Andrew</creatorcontrib><creatorcontrib>Sandler, Dale P</creatorcontrib><creatorcontrib>Taylor, Jack A</creatorcontrib><creatorcontrib>O'Brien, Katie M</creatorcontrib><creatorcontrib>Edwards, Digna R. Velez</creatorcontrib><creatorcontrib>Edwards, Todd L</creatorcontrib><creatorcontrib>Beeghly-Fadiel, Alicia</creatorcontrib><creatorcontrib>Wentzensen, Nicolas</creatorcontrib><creatorcontrib>Pearce, Celeste Leigh</creatorcontrib><creatorcontrib>Wu, Anna H</creatorcontrib><creatorcontrib>Whittemore, Alice S</creatorcontrib><creatorcontrib>McGuire, Valerie</creatorcontrib><creatorcontrib>Sieh, Weiva</creatorcontrib><creatorcontrib>Rothstein, Joseph H</creatorcontrib><creatorcontrib>Modugno, Francesmary</creatorcontrib><creatorcontrib>Ness, Roberta</creatorcontrib><creatorcontrib>Moysich, Kirsten</creatorcontrib><creatorcontrib>Rossing, Mary Anne</creatorcontrib><creatorcontrib>Doherty, Jennifer A</creatorcontrib><creatorcontrib>Sellers, Thomas A</creatorcontrib><creatorcontrib>Permuth-Way, Jennifer B</creatorcontrib><creatorcontrib>Monteiro, Alvaro N</creatorcontrib><creatorcontrib>Levine, Douglas A</creatorcontrib><creatorcontrib>Setiawan, Veronica Wendy</creatorcontrib><creatorcontrib>Haiman, Christopher A</creatorcontrib><creatorcontrib>LeMarchand, Loic</creatorcontrib><creatorcontrib>Wilkens, Lynne R</creatorcontrib><creatorcontrib>Karlan, Beth Y</creatorcontrib><creatorcontrib>Menon, Usha</creatorcontrib><creatorcontrib>Ramus, Susan</creatorcontrib><creatorcontrib>Gayther, Simon</creatorcontrib><creatorcontrib>Gentry-Maharaj, Aleksandra</creatorcontrib><creatorcontrib>Terry, Kathryn L</creatorcontrib><creatorcontrib>Cramer, Daniel W</creatorcontrib><creatorcontrib>Goode, Ellen L</creatorcontrib><creatorcontrib>Larson, Melissa C</creatorcontrib><creatorcontrib>Kaufmann, Scott H</creatorcontrib><creatorcontrib>Cannioto, Rikki</creatorcontrib><creatorcontrib>Odunsi, Kunle</creatorcontrib><creatorcontrib>Etter, John L</creatorcontrib><creatorcontrib>Huang, Ruea-Yea</creatorcontrib><creatorcontrib>Bernardini, Marcus Q</creatorcontrib><creatorcontrib>Tone, Alicia A</creatorcontrib><creatorcontrib>May, Taymaa</creatorcontrib><creatorcontrib>Goodman, Marc T</creatorcontrib><creatorcontrib>Thompson, Pamela J</creatorcontrib><creatorcontrib>Carney, Michael E</creatorcontrib><creatorcontrib>Tworoger, Shelley S</creatorcontrib><creatorcontrib>Poole, Elizabeth M</creatorcontrib><creatorcontrib>Lambrechts, Diether</creatorcontrib><creatorcontrib>Vergote, Ignace</creatorcontrib><creatorcontrib>Vanderstichele, Adriaan</creatorcontrib><creatorcontrib>Van Nieuwenhuysen, Els</creatorcontrib><creatorcontrib>Anton-Culver, Hoda</creatorcontrib><creatorcontrib>Ziogas, Argyrios</creatorcontrib><creatorcontrib>Brenton, James D</creatorcontrib><creatorcontrib>Bjorge, Line</creatorcontrib><creatorcontrib>Salvensen, Helga B</creatorcontrib><creatorcontrib>Kiemeney, Lambertus A</creatorcontrib><creatorcontrib>Massuger, Leon F.A.G</creatorcontrib><creatorcontrib>Pejovic, Tanja</creatorcontrib><creatorcontrib>Bruegl, Amanda</creatorcontrib><creatorcontrib>Moffitt, Melissa</creatorcontrib><creatorcontrib>Cook, Linda</creatorcontrib><creatorcontrib>Le, Nhu D</creatorcontrib><creatorcontrib>Brooks-Wilson, Angela</creatorcontrib><creatorcontrib>Kelemen, Linda E</creatorcontrib><creatorcontrib>Pharoah, Paul D.P</creatorcontrib><creatorcontrib>Song, Honglin</creatorcontrib><creatorcontrib>Campbell, Ian</creatorcontrib><creatorcontrib>Eccles, Diana</creatorcontrib><creatorcontrib>DeFazio, Anna</creatorcontrib><creatorcontrib>Kennedy, Catherine J</creatorcontrib><creatorcontrib>Schildkraut, Joellen M</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>CANCER MEDICINE</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grant, Delores J</au><au>Manichaikul, Ani</au><au>Alberg, Anthony J</au><au>Bandera, Elisa</au><au>Barnholtz-Sloan, Jill</au><au>Bondy, Melissa</au><au>Cote, Michele L</au><au>Funkhouser, Ellen</au><au>Moorman, Patricia G</au><au>Peres, Lauren C</au><au>Peters, Edward S</au><au>Schwartz, Ann G</au><au>Terry, Paul D</au><au>Wang, Xin-Qun</au><au>Keku, Temitope O</au><au>Hoyo, Cathrine</au><au>Berchuck, Andrew</au><au>Sandler, Dale P</au><au>Taylor, Jack A</au><au>O'Brien, Katie M</au><au>Edwards, Digna R. Velez</au><au>Edwards, Todd L</au><au>Beeghly-Fadiel, Alicia</au><au>Wentzensen, Nicolas</au><au>Pearce, Celeste Leigh</au><au>Wu, Anna H</au><au>Whittemore, Alice S</au><au>McGuire, Valerie</au><au>Sieh, Weiva</au><au>Rothstein, Joseph H</au><au>Modugno, Francesmary</au><au>Ness, Roberta</au><au>Moysich, Kirsten</au><au>Rossing, Mary Anne</au><au>Doherty, Jennifer A</au><au>Sellers, Thomas A</au><au>Permuth-Way, Jennifer B</au><au>Monteiro, Alvaro N</au><au>Levine, Douglas A</au><au>Setiawan, Veronica Wendy</au><au>Haiman, Christopher A</au><au>LeMarchand, Loic</au><au>Wilkens, Lynne R</au><au>Karlan, Beth Y</au><au>Menon, Usha</au><au>Ramus, Susan</au><au>Gayther, Simon</au><au>Gentry-Maharaj, Aleksandra</au><au>Terry, Kathryn L</au><au>Cramer, Daniel W</au><au>Goode, Ellen L</au><au>Larson, Melissa C</au><au>Kaufmann, Scott H</au><au>Cannioto, Rikki</au><au>Odunsi, Kunle</au><au>Etter, John L</au><au>Huang, Ruea-Yea</au><au>Bernardini, Marcus Q</au><au>Tone, Alicia A</au><au>May, Taymaa</au><au>Goodman, Marc T</au><au>Thompson, Pamela J</au><au>Carney, Michael E</au><au>Tworoger, Shelley S</au><au>Poole, Elizabeth M</au><au>Lambrechts, Diether</au><au>Vergote, Ignace</au><au>Vanderstichele, Adriaan</au><au>Van Nieuwenhuysen, Els</au><au>Anton-Culver, Hoda</au><au>Ziogas, Argyrios</au><au>Brenton, James D</au><au>Bjorge, Line</au><au>Salvensen, Helga B</au><au>Kiemeney, Lambertus A</au><au>Massuger, Leon F.A.G</au><au>Pejovic, Tanja</au><au>Bruegl, Amanda</au><au>Moffitt, Melissa</au><au>Cook, Linda</au><au>Le, Nhu D</au><au>Brooks-Wilson, Angela</au><au>Kelemen, Linda E</au><au>Pharoah, Paul D.P</au><au>Song, Honglin</au><au>Campbell, Ian</au><au>Eccles, Diana</au><au>DeFazio, Anna</au><au>Kennedy, Catherine J</au><au>Schildkraut, Joellen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women</atitle><jtitle>CANCER MEDICINE</jtitle><date>2019-05</date><risdate>2019</risdate><volume>8</volume><issue>5</issue><spage>2503</spage><epage>2513</epage><pages>2503-2513</pages><issn>2045-7634</issn><eissn>2045-7634</eissn><abstract>An association between genetic variants in the vitamin D receptor (VDR) gene and epithelial ovarian cancer (EOC) was previously reported in women of African ancestry (AA). We sought to examine associations between genetic variants in VDR and additional genes from vitamin D biosynthesis and pathway targets (EGFR, UGT1A, UGT2A1/2, UGT2B, CYP3A4/5, CYP2R1, CYP27B1, CYP24A1, CYP11A1, and GC). Genotyping was performed using the custom-designed 533,631 SNP Illumina OncoArray with imputation to the 1,000 Genomes Phase 3 v5 reference set in 755 EOC cases, including 537 high-grade serous (HGSOC), and 1,235 controls. All subjects are of African ancestry (AA). Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI). We further evaluated statistical significance of selected SNPs using the Bayesian False Discovery Probability (BFDP). A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10-6 , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10-5 , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10-5 , BFDP = 0.23). Genetic variants in the EGFR and UGT2A1/2 may increase susceptibility of EOC in AA women. Future studies to validate these findings are warranted. Alterations in EGFR and UGT2A1/2 could perturb enzyme efficacy, proliferation in ovaries, impact and mark susceptibility to EOC.</abstract><pub>WILEY</pub><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-7634 |
| ispartof | CANCER MEDICINE, 2019-05, Vol.8 (5), p.2503-2513 |
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| source | Wiley Online Library - AutoHoldings Journals; Lirias (KU Leuven Association); Wiley Online Library Open Access; DOAJ Directory of Open Access Journals; PubMed Central; EZB Electronic Journals Library |
| title | Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women |
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