Irf4 Expression in Thymic Epithelium Is Critical for Thymic Regulatory T Cell Homeostasis

The thymus is a primary lymphoid organ required for the induction and maintenance of central tolerance. The main function of the thymus is to generate an immunocompetent set of T cells not reactive to self. During negative selection in the thymus, thymocytes with autoreactive potential are either de...

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Veröffentlicht in:	Journal of Immunology 2017-03, Vol.198 (5), p.1952-1960
Hauptverfasser:	Haljasorg, Uku, Dooley, James, Laan, Martti, Kisand, Kai, Bichele, Rudolf, Liston, Adrian, Peterson, Pärt
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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