Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery

BACKGROUND: Aneuploidy occurs in more than 20% of acute myeloid leukemia (AML) cases and correlates with an adverse prognosis. METHODS: To understand the molecular bases of aneuploid acute myeloid leukemia (A-AML), this study examined the genomic profile in 42 A-AML cases and 35 euploid acute myeloi...

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Veröffentlicht in:	CANCER 2019-03, Vol.125 (5), p.712-725
Hauptverfasser:	Simonetti, Giorgia, Padella, Antonella, do Valle, Italo Faria, Fontana, Maria Chiara, Fonzi, Eugenio, Bruno, Samantha, Baldazzi, Carmen, Guadagnuolo, Viviana, Manfrini, Marco, Ferrari, Anna, Paolini, Stefania, Papayannidis, Cristina, Marconi, Giovanni, Franchini, Eugenia, Zuffa, Elisa, Laginestra, Maria Antonella, Zanotti, Federica, Astolfi, Annalisa, Iacobucci, Ilaria, Bernardi, Simona, Sazzini, Marco, Ficarra, Elisa, Maria Hernandez, Jesus, Vandenberghe, Peter, Cools, Jan, Bullinger, Lars, Ottaviani, Emanuela, Testoni, Nicoletta, Cavo, Michele, Haferlach, Torsten, Castellani, Gastone, Remondini, Daniel, Martinelli, Giovanni
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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