Analgesic properties of opioid/NK1 multi-target ligands with distinct in vitro profiles in naive and chronic constriction injury (CCI)-mice

The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice. Biochemical analysis confirmed the elevated mRNA...

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Veröffentlicht in:	ACS Chemical Neuroscience 2017-07, Vol.8 (10), p.2315-2324
Hauptverfasser:	Starnowska, J, Costante, R, Guillemyn, K, Popiolek-Barczyk, K, Chung, N, Lemieux, C, Keresztes, A, Van Duppen, Joost, Mollica, A, Streicher, J, Vanden Broeck, Jozef, Schiller, P, Tourwé, D, Mika, J, Ballet, S, Przewlocka, B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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