Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)
The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europea...
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| creator | Hein, Rebecca Maranian, Melanie Hopper, John L Kapuscinski, Miroslaw K Southey, Melissa C Park, Daniel J Schmidt, Marjanka K Broeks, Annegien Hogervorst, Frans B.L Bueno-de-Mesquit, H. Bas Muir, Kenneth R Fredericksen, Zachary Giles, Graham G Baglietto, Laura McLean, Catriona A Severi, Gianluca Offit, Kenneth Robson, Mark Gaudet, Mia M Vijai, Joseph Alnæs, Grethe Grenaker Lophatananon, Artitaya Kristensen, Vessela Børresen-Dale, Anne-Lise John, Esther M Miron, Alexander Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L Knight, Julia A Rattanamongkongul, Suthee Glendon, Gord Mulligan, Anna Marie Figueroa, Jonine D García-Closas, Montserrat Lissowska, Jolanta Sherman, Mark E Hooning, Maartje Martens, John W.M Seynaeve, Caroline Collée, Margriet Puttawibul, Puttisak Hall, Per Humpreys, Keith Czene, Kamila Liu, Jianjun Cox, Angela Brock, Ian W Cross, Simon S Reed, Malcolm W.R Ahmed, Shahana Ghoussaini, Maya Fasching, Peter A Pharoah, Paul Dp Kang, Daehee Yoo, Keun-Young Noh, Dong-Young Jakubowska, Anna Jaworska, Katarzyna Durda, Katarzyna Złowocka, Elżbieta Sangrajrang, Suleeporn Gaborieau, Valerie Hein, Alexander Brennan, Paul McKay, James Shen, Chen-Yang Yu, Jyh-Cherng Hsu, Huan-Ming Hou, Ming-Feng Orr, Nick Schoemaker, Minouk Ashworth, Alan Swerdlow, Anthony Ekici, Arif B Trentham-Dietz, Amy Newcomb, Polly A Titus, Linda Egan, Kathleen M Chenevix-Trench, Georgia Antoniou, Antonis C Humphreys, Manjeet K Morrison, Jonathan Chang-Claude, Jenny Easton, Douglas F Beckmann, Matthias W Dunning, Alison M Fletcher, Olivia Johnson, Nichola Dos Santos Silva, Isabel Peto, Julian Sawyer, Elinor Tomlinson, Ian Kerin, Michael Miller, Nicola Marmee, Frederick Schneeweiss, Andreas Sohn, Christof |
| description | The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER-) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26-1.48), p = 7.6×10(-14) in Asians and 1.09 (95% CI 1.07-1.11), p = 6.8×10(-18) in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19-1.41), p = 1.2×10(-9) in Asians and 1.12 (95% CI 1.08-1.17), p = 3.8×10(-9) in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER- than ER+ tumours in Europeans [OR (ER-) = 1.20 (95% CI 1.15-1.25), p = 1.8×10(-17) versus OR (ER+) = 1.07 (95% CI 1.04-1.1), p = 1.3×10(-7), p(heterogeneity) = 5.1×10(-6)]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER- tumours. |
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Bas ; Muir, Kenneth R ; Fredericksen, Zachary ; Giles, Graham G ; Baglietto, Laura ; McLean, Catriona A ; Severi, Gianluca ; Offit, Kenneth ; Robson, Mark ; Gaudet, Mia M ; Vijai, Joseph ; Alnæs, Grethe Grenaker ; Lophatananon, Artitaya ; Kristensen, Vessela ; Børresen-Dale, Anne-Lise ; John, Esther M ; Miron, Alexander ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Andrulis, Irene L ; Knight, Julia A ; Rattanamongkongul, Suthee ; Glendon, Gord ; Mulligan, Anna Marie ; Figueroa, Jonine D ; García-Closas, Montserrat ; Lissowska, Jolanta ; Sherman, Mark E ; Hooning, Maartje ; Martens, John W.M ; Seynaeve, Caroline ; Collée, Margriet ; Puttawibul, Puttisak ; Hall, Per ; Humpreys, Keith ; Czene, Kamila ; Liu, Jianjun ; Cox, Angela ; Brock, Ian W ; Cross, Simon S ; Reed, Malcolm W.R ; Ahmed, Shahana ; Ghoussaini, Maya ; Fasching, Peter A ; Pharoah, Paul Dp ; Kang, Daehee ; Yoo, Keun-Young ; Noh, Dong-Young ; Jakubowska, Anna ; Jaworska, Katarzyna ; Durda, Katarzyna ; Złowocka, Elżbieta ; Sangrajrang, Suleeporn ; Gaborieau, Valerie ; Hein, Alexander ; Brennan, Paul ; McKay, James ; Shen, Chen-Yang ; Yu, Jyh-Cherng ; Hsu, Huan-Ming ; Hou, Ming-Feng ; Orr, Nick ; Schoemaker, Minouk ; Ashworth, Alan ; Swerdlow, Anthony ; Ekici, Arif B ; Trentham-Dietz, Amy ; Newcomb, Polly A ; Titus, Linda ; Egan, Kathleen M ; Chenevix-Trench, Georgia ; Antoniou, Antonis C ; Humphreys, Manjeet K ; Morrison, Jonathan ; Chang-Claude, Jenny ; Easton, Douglas F ; Beckmann, Matthias W ; Dunning, Alison M ; Fletcher, Olivia ; Johnson, Nichola ; Dos Santos Silva, Isabel ; Peto, Julian ; Sawyer, Elinor ; Tomlinson, Ian ; Kerin, Michael ; Miller, Nicola ; Marmee, Frederick ; Schneeweiss, Andreas ; Sohn, Christof</creator><creatorcontrib>Hein, Rebecca ; Maranian, Melanie ; Hopper, John L ; Kapuscinski, Miroslaw K ; Southey, Melissa C ; Park, Daniel J ; Schmidt, Marjanka K ; Broeks, Annegien ; Hogervorst, Frans B.L ; Bueno-de-Mesquit, H. Bas ; Muir, Kenneth R ; Fredericksen, Zachary ; Giles, Graham G ; Baglietto, Laura ; McLean, Catriona A ; Severi, Gianluca ; Offit, Kenneth ; Robson, Mark ; Gaudet, Mia M ; Vijai, Joseph ; Alnæs, Grethe Grenaker ; Lophatananon, Artitaya ; Kristensen, Vessela ; Børresen-Dale, Anne-Lise ; John, Esther M ; Miron, Alexander ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Andrulis, Irene L ; Knight, Julia A ; Rattanamongkongul, Suthee ; Glendon, Gord ; Mulligan, Anna Marie ; Figueroa, Jonine D ; García-Closas, Montserrat ; Lissowska, Jolanta ; Sherman, Mark E ; Hooning, Maartje ; Martens, John W.M ; Seynaeve, Caroline ; Collée, Margriet ; Puttawibul, Puttisak ; Hall, Per ; Humpreys, Keith ; Czene, Kamila ; Liu, Jianjun ; Cox, Angela ; Brock, Ian W ; Cross, Simon S ; Reed, Malcolm W.R ; Ahmed, Shahana ; Ghoussaini, Maya ; Fasching, Peter A ; Pharoah, Paul Dp ; Kang, Daehee ; Yoo, Keun-Young ; Noh, Dong-Young ; Jakubowska, Anna ; Jaworska, Katarzyna ; Durda, Katarzyna ; Złowocka, Elżbieta ; Sangrajrang, Suleeporn ; Gaborieau, Valerie ; Hein, Alexander ; Brennan, Paul ; McKay, James ; Shen, Chen-Yang ; Yu, Jyh-Cherng ; Hsu, Huan-Ming ; Hou, Ming-Feng ; Orr, Nick ; Schoemaker, Minouk ; Ashworth, Alan ; Swerdlow, Anthony ; Ekici, Arif B ; Trentham-Dietz, Amy ; Newcomb, Polly A ; Titus, Linda ; Egan, Kathleen M ; Chenevix-Trench, Georgia ; Antoniou, Antonis C ; Humphreys, Manjeet K ; Morrison, Jonathan ; Chang-Claude, Jenny ; Easton, Douglas F ; Beckmann, Matthias W ; Dunning, Alison M ; Fletcher, Olivia ; Johnson, Nichola ; Dos Santos Silva, Isabel ; Peto, Julian ; Sawyer, Elinor ; Tomlinson, Ian ; Kerin, Michael ; Miller, Nicola ; Marmee, Frederick ; Schneeweiss, Andreas ; Sohn, Christof</creatorcontrib><description>The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER-) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26-1.48), p = 7.6×10(-14) in Asians and 1.09 (95% CI 1.07-1.11), p = 6.8×10(-18) in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19-1.41), p = 1.2×10(-9) in Asians and 1.12 (95% CI 1.08-1.17), p = 3.8×10(-9) in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER- than ER+ tumours in Europeans [OR (ER-) = 1.20 (95% CI 1.15-1.25), p = 1.8×10(-17) versus OR (ER+) = 1.07 (95% CI 1.04-1.1), p = 1.3×10(-7), p(heterogeneity) = 5.1×10(-6)]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER- tumours.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><language>eng</language><publisher>Public Library of Sciene</publisher><ispartof>PLoS One, 2012, Vol.7 (8)</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,780,784,4024,27860</link.rule.ids></links><search><creatorcontrib>Hein, Rebecca</creatorcontrib><creatorcontrib>Maranian, Melanie</creatorcontrib><creatorcontrib>Hopper, John L</creatorcontrib><creatorcontrib>Kapuscinski, Miroslaw K</creatorcontrib><creatorcontrib>Southey, Melissa C</creatorcontrib><creatorcontrib>Park, Daniel J</creatorcontrib><creatorcontrib>Schmidt, Marjanka K</creatorcontrib><creatorcontrib>Broeks, Annegien</creatorcontrib><creatorcontrib>Hogervorst, Frans B.L</creatorcontrib><creatorcontrib>Bueno-de-Mesquit, H. Bas</creatorcontrib><creatorcontrib>Muir, Kenneth R</creatorcontrib><creatorcontrib>Fredericksen, Zachary</creatorcontrib><creatorcontrib>Giles, Graham G</creatorcontrib><creatorcontrib>Baglietto, Laura</creatorcontrib><creatorcontrib>McLean, Catriona A</creatorcontrib><creatorcontrib>Severi, Gianluca</creatorcontrib><creatorcontrib>Offit, Kenneth</creatorcontrib><creatorcontrib>Robson, Mark</creatorcontrib><creatorcontrib>Gaudet, Mia M</creatorcontrib><creatorcontrib>Vijai, Joseph</creatorcontrib><creatorcontrib>Alnæs, Grethe Grenaker</creatorcontrib><creatorcontrib>Lophatananon, Artitaya</creatorcontrib><creatorcontrib>Kristensen, Vessela</creatorcontrib><creatorcontrib>Børresen-Dale, Anne-Lise</creatorcontrib><creatorcontrib>John, Esther M</creatorcontrib><creatorcontrib>Miron, Alexander</creatorcontrib><creatorcontrib>Winqvist, Robert</creatorcontrib><creatorcontrib>Pylkäs, Katri</creatorcontrib><creatorcontrib>Jukkola-Vuorinen, Arja</creatorcontrib><creatorcontrib>Grip, Mervi</creatorcontrib><creatorcontrib>Andrulis, Irene L</creatorcontrib><creatorcontrib>Knight, Julia A</creatorcontrib><creatorcontrib>Rattanamongkongul, Suthee</creatorcontrib><creatorcontrib>Glendon, Gord</creatorcontrib><creatorcontrib>Mulligan, Anna Marie</creatorcontrib><creatorcontrib>Figueroa, Jonine D</creatorcontrib><creatorcontrib>García-Closas, Montserrat</creatorcontrib><creatorcontrib>Lissowska, Jolanta</creatorcontrib><creatorcontrib>Sherman, Mark E</creatorcontrib><creatorcontrib>Hooning, Maartje</creatorcontrib><creatorcontrib>Martens, John W.M</creatorcontrib><creatorcontrib>Seynaeve, Caroline</creatorcontrib><creatorcontrib>Collée, Margriet</creatorcontrib><creatorcontrib>Puttawibul, Puttisak</creatorcontrib><creatorcontrib>Hall, Per</creatorcontrib><creatorcontrib>Humpreys, Keith</creatorcontrib><creatorcontrib>Czene, Kamila</creatorcontrib><creatorcontrib>Liu, Jianjun</creatorcontrib><creatorcontrib>Cox, Angela</creatorcontrib><creatorcontrib>Brock, Ian W</creatorcontrib><creatorcontrib>Cross, Simon S</creatorcontrib><creatorcontrib>Reed, Malcolm W.R</creatorcontrib><creatorcontrib>Ahmed, Shahana</creatorcontrib><creatorcontrib>Ghoussaini, Maya</creatorcontrib><creatorcontrib>Fasching, Peter A</creatorcontrib><creatorcontrib>Pharoah, Paul Dp</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Yoo, Keun-Young</creatorcontrib><creatorcontrib>Noh, Dong-Young</creatorcontrib><creatorcontrib>Jakubowska, Anna</creatorcontrib><creatorcontrib>Jaworska, Katarzyna</creatorcontrib><creatorcontrib>Durda, Katarzyna</creatorcontrib><creatorcontrib>Złowocka, Elżbieta</creatorcontrib><creatorcontrib>Sangrajrang, Suleeporn</creatorcontrib><creatorcontrib>Gaborieau, Valerie</creatorcontrib><creatorcontrib>Hein, Alexander</creatorcontrib><creatorcontrib>Brennan, Paul</creatorcontrib><creatorcontrib>McKay, James</creatorcontrib><creatorcontrib>Shen, Chen-Yang</creatorcontrib><creatorcontrib>Yu, Jyh-Cherng</creatorcontrib><creatorcontrib>Hsu, Huan-Ming</creatorcontrib><creatorcontrib>Hou, Ming-Feng</creatorcontrib><creatorcontrib>Orr, Nick</creatorcontrib><creatorcontrib>Schoemaker, Minouk</creatorcontrib><creatorcontrib>Ashworth, Alan</creatorcontrib><creatorcontrib>Swerdlow, Anthony</creatorcontrib><creatorcontrib>Ekici, Arif B</creatorcontrib><creatorcontrib>Trentham-Dietz, Amy</creatorcontrib><creatorcontrib>Newcomb, Polly A</creatorcontrib><creatorcontrib>Titus, Linda</creatorcontrib><creatorcontrib>Egan, Kathleen M</creatorcontrib><creatorcontrib>Chenevix-Trench, Georgia</creatorcontrib><creatorcontrib>Antoniou, Antonis C</creatorcontrib><creatorcontrib>Humphreys, Manjeet K</creatorcontrib><creatorcontrib>Morrison, Jonathan</creatorcontrib><creatorcontrib>Chang-Claude, Jenny</creatorcontrib><creatorcontrib>Easton, Douglas F</creatorcontrib><creatorcontrib>Beckmann, Matthias W</creatorcontrib><creatorcontrib>Dunning, Alison M</creatorcontrib><creatorcontrib>Fletcher, Olivia</creatorcontrib><creatorcontrib>Johnson, Nichola</creatorcontrib><creatorcontrib>Dos Santos Silva, Isabel</creatorcontrib><creatorcontrib>Peto, Julian</creatorcontrib><creatorcontrib>Sawyer, Elinor</creatorcontrib><creatorcontrib>Tomlinson, Ian</creatorcontrib><creatorcontrib>Kerin, Michael</creatorcontrib><creatorcontrib>Miller, Nicola</creatorcontrib><creatorcontrib>Marmee, Frederick</creatorcontrib><creatorcontrib>Schneeweiss, Andreas</creatorcontrib><creatorcontrib>Sohn, Christof</creatorcontrib><title>Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)</title><title>PLoS One</title><description>The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER-) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26-1.48), p = 7.6×10(-14) in Asians and 1.09 (95% CI 1.07-1.11), p = 6.8×10(-18) in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19-1.41), p = 1.2×10(-9) in Asians and 1.12 (95% CI 1.08-1.17), p = 3.8×10(-9) in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER- than ER+ tumours in Europeans [OR (ER-) = 1.20 (95% CI 1.15-1.25), p = 1.8×10(-17) versus OR (ER+) = 1.07 (95% CI 1.04-1.1), p = 1.3×10(-7), p(heterogeneity) = 5.1×10(-6)]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER- tumours.</description><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqNjMFOwzAQRC0EEqXwD3sDhCqlduM0x9Yq9A4Sx8hKNmKh8QavjfgMPpkcOFScepoZzdM7U7NlbfTC6sKcH_VLdSXyXhSlWVs7Uz-Oh9FHEg7APdhPXcI2opcEzocWI-wpCfSRB9gI-QA-dLDLkUecxhMGHhBeqcPpFm7JJ5pUzyl3hAIUIL3hP-Mx6DgIx0R5gLut27j7a3XR-4PgzV_O1e3j7sXtFx_5gPkLQ9PJ6FtsltqsSlut68bqVVXVZq4eTiOb9J3M6d5f_epkOA</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Hein, Rebecca</creator><creator>Maranian, Melanie</creator><creator>Hopper, John L</creator><creator>Kapuscinski, Miroslaw K</creator><creator>Southey, Melissa C</creator><creator>Park, Daniel J</creator><creator>Schmidt, Marjanka K</creator><creator>Broeks, Annegien</creator><creator>Hogervorst, Frans B.L</creator><creator>Bueno-de-Mesquit, H. 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Bas ; Muir, Kenneth R ; Fredericksen, Zachary ; Giles, Graham G ; Baglietto, Laura ; McLean, Catriona A ; Severi, Gianluca ; Offit, Kenneth ; Robson, Mark ; Gaudet, Mia M ; Vijai, Joseph ; Alnæs, Grethe Grenaker ; Lophatananon, Artitaya ; Kristensen, Vessela ; Børresen-Dale, Anne-Lise ; John, Esther M ; Miron, Alexander ; Winqvist, Robert ; Pylkäs, Katri ; Jukkola-Vuorinen, Arja ; Grip, Mervi ; Andrulis, Irene L ; Knight, Julia A ; Rattanamongkongul, Suthee ; Glendon, Gord ; Mulligan, Anna Marie ; Figueroa, Jonine D ; García-Closas, Montserrat ; Lissowska, Jolanta ; Sherman, Mark E ; Hooning, Maartje ; Martens, John W.M ; Seynaeve, Caroline ; Collée, Margriet ; Puttawibul, Puttisak ; Hall, Per ; Humpreys, Keith ; Czene, Kamila ; Liu, Jianjun ; Cox, Angela ; Brock, Ian W ; Cross, Simon S ; Reed, Malcolm W.R ; Ahmed, Shahana ; Ghoussaini, Maya ; Fasching, Peter A ; Pharoah, Paul Dp ; Kang, Daehee ; Yoo, Keun-Young ; Noh, Dong-Young ; Jakubowska, Anna ; Jaworska, Katarzyna ; Durda, Katarzyna ; Złowocka, Elżbieta ; Sangrajrang, Suleeporn ; Gaborieau, Valerie ; Hein, Alexander ; Brennan, Paul ; McKay, James ; Shen, Chen-Yang ; Yu, Jyh-Cherng ; Hsu, Huan-Ming ; Hou, Ming-Feng ; Orr, Nick ; Schoemaker, Minouk ; Ashworth, Alan ; Swerdlow, Anthony ; Ekici, Arif B ; Trentham-Dietz, Amy ; Newcomb, Polly A ; Titus, Linda ; Egan, Kathleen M ; Chenevix-Trench, Georgia ; Antoniou, Antonis C ; Humphreys, Manjeet K ; Morrison, Jonathan ; Chang-Claude, Jenny ; Easton, Douglas F ; Beckmann, Matthias W ; Dunning, Alison M ; Fletcher, Olivia ; Johnson, Nichola ; Dos Santos Silva, Isabel ; Peto, Julian ; Sawyer, Elinor ; Tomlinson, Ian ; Kerin, Michael ; Miller, Nicola ; Marmee, Frederick ; Schneeweiss, Andreas ; Sohn, Christof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_123456789_6247793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hein, Rebecca</creatorcontrib><creatorcontrib>Maranian, Melanie</creatorcontrib><creatorcontrib>Hopper, John L</creatorcontrib><creatorcontrib>Kapuscinski, Miroslaw K</creatorcontrib><creatorcontrib>Southey, Melissa C</creatorcontrib><creatorcontrib>Park, Daniel J</creatorcontrib><creatorcontrib>Schmidt, Marjanka K</creatorcontrib><creatorcontrib>Broeks, Annegien</creatorcontrib><creatorcontrib>Hogervorst, Frans B.L</creatorcontrib><creatorcontrib>Bueno-de-Mesquit, H. Bas</creatorcontrib><creatorcontrib>Muir, Kenneth R</creatorcontrib><creatorcontrib>Fredericksen, Zachary</creatorcontrib><creatorcontrib>Giles, Graham G</creatorcontrib><creatorcontrib>Baglietto, Laura</creatorcontrib><creatorcontrib>McLean, Catriona A</creatorcontrib><creatorcontrib>Severi, Gianluca</creatorcontrib><creatorcontrib>Offit, Kenneth</creatorcontrib><creatorcontrib>Robson, Mark</creatorcontrib><creatorcontrib>Gaudet, Mia M</creatorcontrib><creatorcontrib>Vijai, Joseph</creatorcontrib><creatorcontrib>Alnæs, Grethe Grenaker</creatorcontrib><creatorcontrib>Lophatananon, Artitaya</creatorcontrib><creatorcontrib>Kristensen, Vessela</creatorcontrib><creatorcontrib>Børresen-Dale, Anne-Lise</creatorcontrib><creatorcontrib>John, Esther M</creatorcontrib><creatorcontrib>Miron, Alexander</creatorcontrib><creatorcontrib>Winqvist, Robert</creatorcontrib><creatorcontrib>Pylkäs, Katri</creatorcontrib><creatorcontrib>Jukkola-Vuorinen, Arja</creatorcontrib><creatorcontrib>Grip, Mervi</creatorcontrib><creatorcontrib>Andrulis, Irene L</creatorcontrib><creatorcontrib>Knight, Julia A</creatorcontrib><creatorcontrib>Rattanamongkongul, Suthee</creatorcontrib><creatorcontrib>Glendon, Gord</creatorcontrib><creatorcontrib>Mulligan, Anna Marie</creatorcontrib><creatorcontrib>Figueroa, Jonine D</creatorcontrib><creatorcontrib>García-Closas, Montserrat</creatorcontrib><creatorcontrib>Lissowska, Jolanta</creatorcontrib><creatorcontrib>Sherman, Mark E</creatorcontrib><creatorcontrib>Hooning, Maartje</creatorcontrib><creatorcontrib>Martens, John W.M</creatorcontrib><creatorcontrib>Seynaeve, Caroline</creatorcontrib><creatorcontrib>Collée, Margriet</creatorcontrib><creatorcontrib>Puttawibul, Puttisak</creatorcontrib><creatorcontrib>Hall, Per</creatorcontrib><creatorcontrib>Humpreys, Keith</creatorcontrib><creatorcontrib>Czene, Kamila</creatorcontrib><creatorcontrib>Liu, Jianjun</creatorcontrib><creatorcontrib>Cox, Angela</creatorcontrib><creatorcontrib>Brock, Ian W</creatorcontrib><creatorcontrib>Cross, Simon S</creatorcontrib><creatorcontrib>Reed, Malcolm W.R</creatorcontrib><creatorcontrib>Ahmed, Shahana</creatorcontrib><creatorcontrib>Ghoussaini, Maya</creatorcontrib><creatorcontrib>Fasching, Peter A</creatorcontrib><creatorcontrib>Pharoah, Paul Dp</creatorcontrib><creatorcontrib>Kang, Daehee</creatorcontrib><creatorcontrib>Yoo, Keun-Young</creatorcontrib><creatorcontrib>Noh, Dong-Young</creatorcontrib><creatorcontrib>Jakubowska, Anna</creatorcontrib><creatorcontrib>Jaworska, Katarzyna</creatorcontrib><creatorcontrib>Durda, Katarzyna</creatorcontrib><creatorcontrib>Złowocka, Elżbieta</creatorcontrib><creatorcontrib>Sangrajrang, Suleeporn</creatorcontrib><creatorcontrib>Gaborieau, Valerie</creatorcontrib><creatorcontrib>Hein, Alexander</creatorcontrib><creatorcontrib>Brennan, Paul</creatorcontrib><creatorcontrib>McKay, James</creatorcontrib><creatorcontrib>Shen, Chen-Yang</creatorcontrib><creatorcontrib>Yu, Jyh-Cherng</creatorcontrib><creatorcontrib>Hsu, Huan-Ming</creatorcontrib><creatorcontrib>Hou, Ming-Feng</creatorcontrib><creatorcontrib>Orr, Nick</creatorcontrib><creatorcontrib>Schoemaker, Minouk</creatorcontrib><creatorcontrib>Ashworth, Alan</creatorcontrib><creatorcontrib>Swerdlow, Anthony</creatorcontrib><creatorcontrib>Ekici, Arif B</creatorcontrib><creatorcontrib>Trentham-Dietz, Amy</creatorcontrib><creatorcontrib>Newcomb, Polly A</creatorcontrib><creatorcontrib>Titus, Linda</creatorcontrib><creatorcontrib>Egan, Kathleen M</creatorcontrib><creatorcontrib>Chenevix-Trench, Georgia</creatorcontrib><creatorcontrib>Antoniou, Antonis C</creatorcontrib><creatorcontrib>Humphreys, Manjeet K</creatorcontrib><creatorcontrib>Morrison, Jonathan</creatorcontrib><creatorcontrib>Chang-Claude, Jenny</creatorcontrib><creatorcontrib>Easton, Douglas F</creatorcontrib><creatorcontrib>Beckmann, Matthias W</creatorcontrib><creatorcontrib>Dunning, Alison M</creatorcontrib><creatorcontrib>Fletcher, Olivia</creatorcontrib><creatorcontrib>Johnson, Nichola</creatorcontrib><creatorcontrib>Dos Santos Silva, Isabel</creatorcontrib><creatorcontrib>Peto, Julian</creatorcontrib><creatorcontrib>Sawyer, Elinor</creatorcontrib><creatorcontrib>Tomlinson, Ian</creatorcontrib><creatorcontrib>Kerin, Michael</creatorcontrib><creatorcontrib>Miller, Nicola</creatorcontrib><creatorcontrib>Marmee, Frederick</creatorcontrib><creatorcontrib>Schneeweiss, Andreas</creatorcontrib><creatorcontrib>Sohn, Christof</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>PLoS One</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hein, Rebecca</au><au>Maranian, Melanie</au><au>Hopper, John L</au><au>Kapuscinski, Miroslaw K</au><au>Southey, Melissa C</au><au>Park, Daniel J</au><au>Schmidt, Marjanka K</au><au>Broeks, Annegien</au><au>Hogervorst, Frans B.L</au><au>Bueno-de-Mesquit, H. Bas</au><au>Muir, Kenneth R</au><au>Fredericksen, Zachary</au><au>Giles, Graham G</au><au>Baglietto, Laura</au><au>McLean, Catriona A</au><au>Severi, Gianluca</au><au>Offit, Kenneth</au><au>Robson, Mark</au><au>Gaudet, Mia M</au><au>Vijai, Joseph</au><au>Alnæs, Grethe Grenaker</au><au>Lophatananon, Artitaya</au><au>Kristensen, Vessela</au><au>Børresen-Dale, Anne-Lise</au><au>John, Esther M</au><au>Miron, Alexander</au><au>Winqvist, Robert</au><au>Pylkäs, Katri</au><au>Jukkola-Vuorinen, Arja</au><au>Grip, Mervi</au><au>Andrulis, Irene L</au><au>Knight, Julia A</au><au>Rattanamongkongul, Suthee</au><au>Glendon, Gord</au><au>Mulligan, Anna Marie</au><au>Figueroa, Jonine D</au><au>García-Closas, Montserrat</au><au>Lissowska, Jolanta</au><au>Sherman, Mark E</au><au>Hooning, Maartje</au><au>Martens, John W.M</au><au>Seynaeve, Caroline</au><au>Collée, Margriet</au><au>Puttawibul, Puttisak</au><au>Hall, Per</au><au>Humpreys, Keith</au><au>Czene, Kamila</au><au>Liu, Jianjun</au><au>Cox, Angela</au><au>Brock, Ian W</au><au>Cross, Simon S</au><au>Reed, Malcolm W.R</au><au>Ahmed, Shahana</au><au>Ghoussaini, Maya</au><au>Fasching, Peter A</au><au>Pharoah, Paul Dp</au><au>Kang, Daehee</au><au>Yoo, Keun-Young</au><au>Noh, Dong-Young</au><au>Jakubowska, Anna</au><au>Jaworska, Katarzyna</au><au>Durda, Katarzyna</au><au>Złowocka, Elżbieta</au><au>Sangrajrang, Suleeporn</au><au>Gaborieau, Valerie</au><au>Hein, Alexander</au><au>Brennan, Paul</au><au>McKay, James</au><au>Shen, Chen-Yang</au><au>Yu, Jyh-Cherng</au><au>Hsu, Huan-Ming</au><au>Hou, Ming-Feng</au><au>Orr, Nick</au><au>Schoemaker, Minouk</au><au>Ashworth, Alan</au><au>Swerdlow, Anthony</au><au>Ekici, Arif B</au><au>Trentham-Dietz, Amy</au><au>Newcomb, Polly A</au><au>Titus, Linda</au><au>Egan, Kathleen M</au><au>Chenevix-Trench, Georgia</au><au>Antoniou, Antonis C</au><au>Humphreys, Manjeet K</au><au>Morrison, Jonathan</au><au>Chang-Claude, Jenny</au><au>Easton, Douglas F</au><au>Beckmann, Matthias W</au><au>Dunning, Alison M</au><au>Fletcher, Olivia</au><au>Johnson, Nichola</au><au>Dos Santos Silva, Isabel</au><au>Peto, Julian</au><au>Sawyer, Elinor</au><au>Tomlinson, Ian</au><au>Kerin, Michael</au><au>Miller, Nicola</au><au>Marmee, Frederick</au><au>Schneeweiss, Andreas</au><au>Sohn, Christof</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)</atitle><jtitle>PLoS One</jtitle><date>2012</date><risdate>2012</risdate><volume>7</volume><issue>8</issue><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The 6q25.1 locus was first identified via a genome-wide association study (GWAS) in Chinese women and marked by single nucleotide polymorphism (SNP) rs2046210, approximately 180 Kb upstream of ESR1. There have been conflicting reports about the association of this locus with breast cancer in Europeans, and a GWAS in Europeans identified a different SNP, tagged here by rs12662670. We examined the associations of both SNPs in up to 61,689 cases and 58,822 controls from forty-four studies collaborating in the Breast Cancer Association Consortium, of which four studies were of Asian and 39 of European descent. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Case-only analyses were used to compare SNP effects in Estrogen Receptor positive (ER+) versus negative (ER-) tumours. Models including both SNPs were fitted to investigate whether the SNP effects were independent. Both SNPs are significantly associated with breast cancer risk in both ethnic groups. Per-allele ORs are higher in Asian than in European studies [rs2046210: OR (A/G) = 1.36 (95% CI 1.26-1.48), p = 7.6×10(-14) in Asians and 1.09 (95% CI 1.07-1.11), p = 6.8×10(-18) in Europeans. rs12662670: OR (G/T) = 1.29 (95% CI 1.19-1.41), p = 1.2×10(-9) in Asians and 1.12 (95% CI 1.08-1.17), p = 3.8×10(-9) in Europeans]. SNP rs2046210 is associated with a significantly greater risk of ER- than ER+ tumours in Europeans [OR (ER-) = 1.20 (95% CI 1.15-1.25), p = 1.8×10(-17) versus OR (ER+) = 1.07 (95% CI 1.04-1.1), p = 1.3×10(-7), p(heterogeneity) = 5.1×10(-6)]. In these Asian studies, by contrast, there is no clear evidence of a differential association by tumour receptor status. Each SNP is associated with risk after adjustment for the other SNP. These results suggest the presence of two variants at 6q25.1 each independently associated with breast cancer risk in Asians and in Europeans. Of these two, the one tagged by rs2046210 is associated with a greater risk of ER- tumours.</abstract><pub>Public Library of Sciene</pub><oa>free_for_read</oa></addata></record> |
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| title | Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC) |
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