eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1

The actin cytoskeleton coordinates the organization of signaling microclusters at the immune synapse (IS); however, the mechanisms involved remain poorly understood. We show here that nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) controls the coalescence of protein kinase C...

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Veröffentlicht in:	PLOS BIOLOGY 2017-04, Vol.15 (4)
Hauptverfasser:	Garcia-Ortiz, Almudena, Martin-Cofreces, Noa B, Ibiza, Sales, Ortega, Angel, Izquierdo-Alvarez, Alicia, Trullo, Antonio, Victor, Victor M, Calvo, Enrique, Sot, Begona, Martinez-Ruiz, Antonio, Vazquez, Jesus, Sanchez-Madrid, Francisco, Serrador, Juan M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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