Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.

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Veröffentlicht in:British Journal of Cancer 2018-04, Vol.118 (8), p.1123-1129
Hauptverfasser: Dixon-Suen, Suzanne C, Nagle, Christina M, Thrift, Aaron P, Pharoah, Paul D.P, Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Chang-Claude, Jenny, Jung, Audrey Y, Moysich, Kirsten B, Odunsi, Kunle, Goodman, Marc T, Wilkens, Lynne R, Thompson, Pamela J, Shvetsov, Yurii B, Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Kelley, Joseph L, Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y, Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Winham, Stacey J, Giles, Graham G, Bruinsma, Fiona, Milne, Roger L, Southey, Melissa C, Hildebrandt, Michelle A.T, Wu, Xifeng, Lu, Karen H, Liang, Dong, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Olson, Sara H, Salvesen, Helga B, Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon F.A.G, Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S, Le, Nhu D, Swenerton, Kenneth D, Brooks-Wilson, Angela, Kelemen, Linda E, Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K, Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P, Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, Whittemore, Alice S
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container_issue 8
container_start_page 1123
container_title British Journal of Cancer
container_volume 118
creator Dixon-Suen, Suzanne C
Nagle, Christina M
Thrift, Aaron P
Pharoah, Paul D.P
Ewing, Ailith
Pearce, Celeste Leigh
Zheng, Wei
Australian Ovarian Cancer Study Group
Chenevix-Trench, Georgia
Fasching, Peter A
Beckmann, Matthias W
Lambrechts, Diether
Vergote, Ignace
Lambrechts, Sandrina
Van Nieuwenhuysen, Els
Rossing, Mary Anne
Doherty, Jennifer A
Wicklund, Kristine G
Chang-Claude, Jenny
Jung, Audrey Y
Moysich, Kirsten B
Odunsi, Kunle
Goodman, Marc T
Wilkens, Lynne R
Thompson, Pamela J
Shvetsov, Yurii B
Dörk, Thilo
Park-Simon, Tjoung-Won
Hillemanns, Peter
Bogdanova, Natalia
Butzow, Ralf
Nevanlinna, Heli
Pelttari, Liisa M
Leminen, Arto
Modugno, Francesmary
Ness, Roberta B
Edwards, Robert P
Kelley, Joseph L
Heitz, Florian
du Bois, Andreas
Harter, Philipp
Schwaab, Ira
Karlan, Beth Y
Lester, Jenny
Orsulic, Sandra
Rimel, Bobbie J
Kjær, Susanne K
Høgdall, Estrid
Jensen, Allan
Goode, Ellen L
Fridley, Brooke L
Cunningham, Julie M
Winham, Stacey J
Giles, Graham G
Bruinsma, Fiona
Milne, Roger L
Southey, Melissa C
Hildebrandt, Michelle A.T
Wu, Xifeng
Lu, Karen H
Liang, Dong
Levine, Douglas A
Bisogna, Maria
Schildkraut, Joellen M
Berchuck, Andrew
Cramer, Daniel W
Terry, Kathryn L
Bandera, Elisa V
Olson, Sara H
Salvesen, Helga B
Thomsen, Liv Cecilie Vestrheim
Kopperud, Reidun K
Bjorge, Line
Kiemeney, Lambertus A
Massuger, Leon F.A.G
Pejovic, Tanja
Bruegl, Amanda
Cook, Linda S
Le, Nhu D
Swenerton, Kenneth D
Brooks-Wilson, Angela
Kelemen, Linda E
Lubiński, Jan
Huzarski, Tomasz
Gronwald, Jacek
Menkiszak, Janusz
Wentzensen, Nicolas
Brinton, Louise
Yang, Hannah
Lissowska, Jolanta
Høgdall, Claus K
Lundvall, Lene
Song, Honglin
Tyrer, Jonathan P
Campbell, Ian
Eccles, Diana
Paul, James
Glasspool, Rosalind
Siddiqui, Nadeem
Whittemore, Alice S
description Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.
format Article
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Bogdanova, Natalia ; Butzow, Ralf ; Nevanlinna, Heli ; Pelttari, Liisa M ; Leminen, Arto ; Modugno, Francesmary ; Ness, Roberta B ; Edwards, Robert P ; Kelley, Joseph L ; Heitz, Florian ; du Bois, Andreas ; Harter, Philipp ; Schwaab, Ira ; Karlan, Beth Y ; Lester, Jenny ; Orsulic, Sandra ; Rimel, Bobbie J ; Kjær, Susanne K ; Høgdall, Estrid ; Jensen, Allan ; Goode, Ellen L ; Fridley, Brooke L ; Cunningham, Julie M ; Winham, Stacey J ; Giles, Graham G ; Bruinsma, Fiona ; Milne, Roger L ; Southey, Melissa C ; Hildebrandt, Michelle A.T ; Wu, Xifeng ; Lu, Karen H ; Liang, Dong ; Levine, Douglas A ; Bisogna, Maria ; Schildkraut, Joellen M ; Berchuck, Andrew ; Cramer, Daniel W ; Terry, Kathryn L ; Bandera, Elisa V ; Olson, Sara H ; Salvesen, Helga B ; Thomsen, Liv Cecilie Vestrheim ; Kopperud, Reidun K ; Bjorge, Line ; Kiemeney, Lambertus A ; Massuger, Leon F.A.G ; Pejovic, Tanja ; Bruegl, Amanda ; Cook, Linda S ; Le, Nhu D ; Swenerton, Kenneth D ; Brooks-Wilson, Angela ; Kelemen, Linda E ; 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P</au><au>Pharoah, Paul D.P</au><au>Ewing, Ailith</au><au>Pearce, Celeste Leigh</au><au>Zheng, Wei</au><au>Australian Ovarian Cancer Study Group</au><au>Chenevix-Trench, Georgia</au><au>Fasching, Peter A</au><au>Beckmann, Matthias W</au><au>Lambrechts, Diether</au><au>Vergote, Ignace</au><au>Lambrechts, Sandrina</au><au>Van Nieuwenhuysen, Els</au><au>Rossing, Mary Anne</au><au>Doherty, Jennifer A</au><au>Wicklund, Kristine G</au><au>Chang-Claude, Jenny</au><au>Jung, Audrey Y</au><au>Moysich, Kirsten B</au><au>Odunsi, Kunle</au><au>Goodman, Marc T</au><au>Wilkens, Lynne R</au><au>Thompson, Pamela J</au><au>Shvetsov, Yurii B</au><au>Dörk, Thilo</au><au>Park-Simon, Tjoung-Won</au><au>Hillemanns, Peter</au><au>Bogdanova, Natalia</au><au>Butzow, Ralf</au><au>Nevanlinna, Heli</au><au>Pelttari, Liisa M</au><au>Leminen, Arto</au><au>Modugno, Francesmary</au><au>Ness, Roberta B</au><au>Edwards, Robert P</au><au>Kelley, Joseph L</au><au>Heitz, Florian</au><au>du Bois, Andreas</au><au>Harter, 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Angela</au><au>Kelemen, Linda E</au><au>Lubiński, Jan</au><au>Huzarski, Tomasz</au><au>Gronwald, Jacek</au><au>Menkiszak, Janusz</au><au>Wentzensen, Nicolas</au><au>Brinton, Louise</au><au>Yang, Hannah</au><au>Lissowska, Jolanta</au><au>Høgdall, Claus K</au><au>Lundvall, Lene</au><au>Song, Honglin</au><au>Tyrer, Jonathan P</au><au>Campbell, Ian</au><au>Eccles, Diana</au><au>Paul, James</au><au>Glasspool, Rosalind</au><au>Siddiqui, Nadeem</au><au>Whittemore, Alice S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study</atitle><jtitle>British Journal of Cancer</jtitle><date>2018-04</date><risdate>2018</risdate><volume>118</volume><issue>8</issue><spage>1123</spage><epage>1129</epage><pages>1123-1129</pages><issn>0007-0920</issn><abstract>Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.</abstract><pub>Harcourt Publishers</pub><oa>free_for_read</oa></addata></record>
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title Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study
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