Adaptive antibody diversification through-linked glycosylation of the immunoglobulin variable region

A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually defined in terms of amino acid composition. However, variable domains may also acquire-linked glycans, a process conditional on the introductio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences of the United States of America 2018-02, Vol.115 (8), p.1901-1906
Hauptverfasser:	van de Bovenkamp, Fleur S, Derksen, Ninotska I.L, Ooijevaar-de Heer, Pleuni, van Schie, Karin A, Kruithof, Simone, Berkowska, Magdalena A, van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E.M, Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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