A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover

Mutations in LRRK2 are a common cause of genetic Parkinson's disease (PD). LRRK2 is a multi-domain Roco protein, harbouring kinase and GTPase activity. In analogy with a bacterial homologue, LRRK2 was proposed to act as a GTPase activated by dimerization (GAD), while recent reports suggest LRRK...

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Veröffentlicht in:	Nature Communications 2017-10, Vol.8 (1)
Hauptverfasser:	Deyaert, Egon, Wauters, Lina, Guaitoli, Giambattista, Konijnenberg, Albert, Leemans, Margaux, Terheyden, Susanne, Petrovic, Arsen, Gallardo, Rodrigo, Nederveen-Schippers, Laura M, Athanasopoulos, Panagiotis S, Pots, Henderikus, Van Haastert, Peter J.M, Sobott, Frank, Gloeckner, Christian Johannes, Efremov, Rouslan, Kortholt, Arjan, Versees, Wim
Format:	Artikel
Sprache:	eng
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