Tapinarof Is a Natural AhR Agonist that Resolves Skin Inflammation in Mice and Humans

Tapinarof (GSK2894512) is a naturally derived topical treatment with demonstrated efficacy for patients with psoriasis and atopic dermatitis, although the biologic target and mechanism of action had been unknown. We demonstrate that the anti-inflammatory properties of tapinarof are mediated through...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of Investigative Dermatology 2017-10, Vol.137 (10), p.2110-2119
Hauptverfasser:	Smith, Susan H, Jayawickreme, Channa, Rickard, David J, Nicodeme, Edwige, Bui, Thi, Simmons, Cathy, Coquery, Christine M, Neil, Jessica, Pryor, William M, Mayhew, David, Rajpal, Deepak K, Creech, Katrina, Furst, Sylvia, Lee, James, Wu, Dalei, Rastinejad, Fraydoon, Willson, Timothy M, Viviani, Fabrice, Morris, David C, Moore, John T, Cote-Sierra, Javier
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!