Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients

Whether the combined use of probe drugs for CYP3A4 and P-glycoprotein can clarify the relative contribution of these proteins to pharmacokinetic variability of a dual substrate like tacrolimus has never been assessed. Seventy renal recipients underwent simultaneous 8-h pharmacokinetic profiles for t...

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Veröffentlicht in:	Clinical Pharmacology and Therapeutics 2017-12, Vol.102 (6), p.989-996
Hauptverfasser:	Vanhove, Thomas, Bouillon, Thomas, de Loor, H, Annaert, Pieter, Kuypers, Dirk
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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