Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues

A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Bioorganic & Medicinal Chemistry Letters 2001-09, Vol.11 (17), p.2229-34
Hauptverfasser: Ludovici, D.W, Kavash, R.W, Kukla, M.J, Ho, C.Y, Ye, H, De Corte, B.L, Andries, K, de Béthune, M.P, Azijn, H, Pauwels, R, Moereels, H.E, Heeres, J, Koymans, L.M, de Jonge, M.R, Van Aken, K.J, Daeyaert, F.F, Lewi, P.J, Das, Kalyan, Arnold, E, Janssen, P.A
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.
ISSN:0960-894X