ADAMTS13 glycans and conformation-dependent activity

ADAMTS13 glycans and conformation-dependent activity

ADAMTS13 activity can be regulated by its conformation where interactions between the C-terminal CUB domains and the Spacer domain maintain ADAMTS13 in a closed conformation. ADAMTS13 contains 10 N-linked glycans, with four sites present in the TSP2 through CUB domains that may contribute to its con...

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Veröffentlicht in:Journal of Thrombosis and Haemostasis 2017-06, Vol.15 (6), p.1155-1166
Hauptverfasser: Nowak, A.A, O'Brien, H.E.R, Henne, P, Doerr, A, Vanhoorelbeke, Karen, Laffan, M.A, McKinnon, T.A.J
Format: Artikel
Sprache:eng
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Zusammenfassung:ADAMTS13 activity can be regulated by its conformation where interactions between the C-terminal CUB domains and the Spacer domain maintain ADAMTS13 in a closed conformation. ADAMTS13 contains 10 N-linked glycans, with four sites present in the TSP2 through CUB domains that may contribute to its conformation.
ISSN:1538-7933