Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization

A novel series of uracil-bearing DAPYs derivatives were designed and synthesized via structure-based molecular hybridization to discover compounds with improved anti-resistance profiles. Anti-HIV activity of the designed compounds was tested in MT-4 cell cultures. The most promising compound 16d sho...

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Veröffentlicht in:	European Journal of Medicinal Chemistry 2017-04, Vol.130, p.209-222
Hauptverfasser:	Zhang, Heng, Tian, Ye, Kang, Dongwei, Huo, Zhipeng, Zhou, Zhongxia, Liu, Huiqing, De Clercq, Erik, Pannecouque, Christophe, Zhan, Peng, Liu, Xinyong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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