Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients

Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients

DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA damage repair during platinum-based chemotherapy may cause...

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Veröffentlicht in:Clinical Cancer Research 2017-05, Vol.23 (9), p.2213-2222
Hauptverfasser: Flanagan, James M, Wilson, Angela, Koo, Chail, Masrour, Nahal, Gallon, John, Loomis, Erick, Flower, Kirsty, Wilhelm-Benartzi, Charlotte, Hergovich, Alexander, Cunnea, Paula, Gabra, Hani, Braicu, Elena I, Sehouli, Jalid, Darb-Esfahani, Silvia, Vanderstichele, Adriaan, Vergote, Ignace, Kreuzinger, Caroline, Cacsire Castillo-Tong, Dan, Wisman, Gijsbertha Ba, Berns, Els M.J.J, Siddiqui, Nadeem, Brown, Robert
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Sprache:eng
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Zusammenfassung:DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA damage repair during platinum-based chemotherapy may cause aberrant DNA methylation in normal tissues of patients such as blood.
ISSN:1078-0432