Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors

Ecto-nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) is the most important member of the NPP family, which consists of seven closely related proteins (NPP1-NPP7). This glycoprotein is a membraneassociated or secreted enzyme, which catalyzes the hydrolysis of a wide range of phosphodiester bonds...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & Medicinal Chemistry 2016, Vol.24 (14), p.3157-3165
Hauptverfasser:	Lee, Sang-Yong, Perotti, Arianna, De Jonghe, Steven, Herdewijn, Piet, Hanck, Theodor, Mueller, Christa E
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!