The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide

Treatment-induced mutations in the ligand-binding domain of the androgen receptor (AR) are known to change antagonists into agonists. Recently, the F877L mutation has been described to convert enzalutamide into an agonist. This mutation was seen to co-occur in the endogenous AR allele of LNCaP cells...

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Veröffentlicht in:	MOLECULAR CANCER THERAPEUTICS 2016-07, Vol.15 (7), p.1702-1712
Hauptverfasser:	Prekovic, Stefan, van Royen, Martin E, Voet, Arnout R.D, Geverts, Bart, Houtman, Rene, Melchers, Diana, Zhang, Kam Y.J, Van den Broeck, Thomas, Smeets, Elien, Spans, Lien, Houtsmuller, Adriaan B, Joniau, Steven, Claessens, Frank, Helsen, Christine
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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