PTEN recruitment controls synaptic and cognitive function in Alzheimer's models

Dyshomeostasis of amyloid-β peptide (Aβ) is responsible for synaptic malfunctions leading to cognitive deficits ranging from mild impairment to full-blown dementia in Alzheimer's disease. Aβ appears to skew synaptic plasticity events toward depression. We found that inhibition of PTEN, a lipid...

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Veröffentlicht in:	Nature Neuroscience 2016-03, Vol.19 (3), p.443-53
Hauptverfasser:	Knafo, Shira, Sánchez-Puelles, Cristina, Palomer, Ernest, Delgado, Igotz, Draffin, Jonathan E, Mingo, Janire, Wahle, Tina, Kaleka, Kanwardeep, Mou, Liping, Pereda-Perez, Inmaculada, Klosi, Edvin, Faber, Erik B, Chapman, Heidi M, Lozano-Montes, Laura, Ortega-Molina, Ana, Ordóñez-Gutiérrez, Lara, Wandosell, Francisco, Viña, Jose, Dotti, Carlos, Hall, Randy A, Pulido, Rafael, Gerges, Nashaat Z, Chan, Andrew M, Spaller, Mark R, Serrano, Manuel, Venero, César, Esteban, José A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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