The latent structure of the functional dyspepsia symptom complex: A taxometric analysis
OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We ai...
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| Veröffentlicht in: | Neurogastroenterology and Motility 2016, Vol.28 (7), p.985-993 |
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| container_title | Neurogastroenterology and Motility |
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| creator | Van Oudenhove, Lukas Jasper, F Walentynowicz, Marta Witthöft, M Van den Bergh, Omer Tack, Jan |
| description | OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist. METHODS: Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD. KEY RESULTS: Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p |
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| fullrecord | <record><control><sourceid>kuleuven</sourceid><recordid>TN_cdi_kuleuven_dspace_123456789_527105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>123456789_527105</sourcerecordid><originalsourceid>FETCH-kuleuven_dspace_123456789_5271053</originalsourceid><addsrcrecordid>eNqVyk0KwjAQQOEsFKw_d5idCxHS1lTrTkTxAILLEtIpVtMmdCbS3l4XHkBXDx7fSERxquQ6zhM1EVOih5QySzZZJG7XO4LVjC0DcRcMhw7BVcCfX4XWcO1abaEcyKOnWgMNjWfXgHGNt9jv4QCse9cgd7UB_cED1TQX40pbwsW3M7E8n67Hy_oZLIYXtkVJXhss4iTdqGy7ywuVbGOp0n_k6jdZcM_pG16-UFU</addsrcrecordid><sourcetype>Institutional Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The latent structure of the functional dyspepsia symptom complex: A taxometric analysis</title><source>Lirias (KU Leuven Association)</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><creator>Van Oudenhove, Lukas ; Jasper, F ; Walentynowicz, Marta ; Witthöft, M ; Van den Bergh, Omer ; Tack, Jan</creator><creatorcontrib>Van Oudenhove, Lukas ; Jasper, F ; Walentynowicz, Marta ; Witthöft, M ; Van den Bergh, Omer ; Tack, Jan</creatorcontrib><description>OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist. METHODS: Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD. KEY RESULTS: Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p < 0.001). All symptoms had significant loadings on both the general and the subgroup-specific factors (all p < 0.05). Somatization was associated with the general (r = 0.72, p < 0.01), but not the subgroup-specific factors (all r < 0.13, p > 0.05). Taxometric analyses supported a dimensional structure of FD (all CCFI<0.38). CONCLUSIONS AND INFERENCES: We found a dimensional rather than categorical latent structure of the FD symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom-specific factors reflecting the Rome III subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of FD.</description><identifier>ISSN: 1350-1925</identifier><language>eng</language><publisher>Blackwell Science</publisher><ispartof>Neurogastroenterology and Motility, 2016, Vol.28 (7), p.985-993</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,4010,27837</link.rule.ids></links><search><creatorcontrib>Van Oudenhove, Lukas</creatorcontrib><creatorcontrib>Jasper, F</creatorcontrib><creatorcontrib>Walentynowicz, Marta</creatorcontrib><creatorcontrib>Witthöft, M</creatorcontrib><creatorcontrib>Van den Bergh, Omer</creatorcontrib><creatorcontrib>Tack, Jan</creatorcontrib><title>The latent structure of the functional dyspepsia symptom complex: A taxometric analysis</title><title>Neurogastroenterology and Motility</title><description>OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist. METHODS: Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD. KEY RESULTS: Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p < 0.001). All symptoms had significant loadings on both the general and the subgroup-specific factors (all p < 0.05). Somatization was associated with the general (r = 0.72, p < 0.01), but not the subgroup-specific factors (all r < 0.13, p > 0.05). Taxometric analyses supported a dimensional structure of FD (all CCFI<0.38). CONCLUSIONS AND INFERENCES: We found a dimensional rather than categorical latent structure of the FD symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom-specific factors reflecting the Rome III subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of FD.</description><issn>1350-1925</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVyk0KwjAQQOEsFKw_d5idCxHS1lTrTkTxAILLEtIpVtMmdCbS3l4XHkBXDx7fSERxquQ6zhM1EVOih5QySzZZJG7XO4LVjC0DcRcMhw7BVcCfX4XWcO1abaEcyKOnWgMNjWfXgHGNt9jv4QCse9cgd7UB_cED1TQX40pbwsW3M7E8n67Hy_oZLIYXtkVJXhss4iTdqGy7ywuVbGOp0n_k6jdZcM_pG16-UFU</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Van Oudenhove, Lukas</creator><creator>Jasper, F</creator><creator>Walentynowicz, Marta</creator><creator>Witthöft, M</creator><creator>Van den Bergh, Omer</creator><creator>Tack, Jan</creator><general>Blackwell Science</general><scope>FZOIL</scope></search><sort><creationdate>2016</creationdate><title>The latent structure of the functional dyspepsia symptom complex: A taxometric analysis</title><author>Van Oudenhove, Lukas ; Jasper, F ; Walentynowicz, Marta ; Witthöft, M ; Van den Bergh, Omer ; Tack, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_123456789_5271053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Oudenhove, Lukas</creatorcontrib><creatorcontrib>Jasper, F</creatorcontrib><creatorcontrib>Walentynowicz, Marta</creatorcontrib><creatorcontrib>Witthöft, M</creatorcontrib><creatorcontrib>Van den Bergh, Omer</creatorcontrib><creatorcontrib>Tack, Jan</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>Neurogastroenterology and Motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Oudenhove, Lukas</au><au>Jasper, F</au><au>Walentynowicz, Marta</au><au>Witthöft, M</au><au>Van den Bergh, Omer</au><au>Tack, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The latent structure of the functional dyspepsia symptom complex: A taxometric analysis</atitle><jtitle>Neurogastroenterology and Motility</jtitle><date>2016</date><risdate>2016</risdate><volume>28</volume><issue>7</issue><spage>985</spage><epage>993</epage><pages>985-993</pages><issn>1350-1925</issn><abstract>OBJECTIVES: Rome III introduced a subdivision of functional dyspepsia (FD) into postprandial distress syndrome and epigastric pain syndrome, characterized by early satiation/postprandial fullness, and epigastric pain/burning, respectively. However, evidence on their degree of overlap is mixed. We aimed to investigate the latent structure of FD to test whether distinguishable symptom-based subgroups exist. METHODS: Consecutive tertiary care Rome II FD patients completed the dyspepsia symptom severity scale. Confirmatory factor analysis (CFA) was used to compare the fit of a single factor model, a correlated three-factor model based on Rome III subgroups and a bifactor model consisting of a general FD factor and orthogonal subgroup factors. Taxometric analyses were subsequently used to investigate the latent structure of FD. KEY RESULTS: Nine hundred and fifty-seven FD patients (71.1% women, age 41 ± 14.8) participated. In CFA, the bifactor model yielded a significantly better fit than the two other models (χ² difference tests both p < 0.001). All symptoms had significant loadings on both the general and the subgroup-specific factors (all p < 0.05). Somatization was associated with the general (r = 0.72, p < 0.01), but not the subgroup-specific factors (all r < 0.13, p > 0.05). Taxometric analyses supported a dimensional structure of FD (all CCFI<0.38). CONCLUSIONS AND INFERENCES: We found a dimensional rather than categorical latent structure of the FD symptom complex in tertiary care. A combination of a general dyspepsia symptom reporting factor, which was associated with somatization, and symptom-specific factors reflecting the Rome III subdivision fitted the data best. This has implications for classification, pathophysiology, and treatment of FD.</abstract><pub>Blackwell Science</pub><oa>free_for_read</oa></addata></record> |
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| title | The latent structure of the functional dyspepsia symptom complex: A taxometric analysis |
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