2-(2,4-Dioxy-1,2,3,4-tetrahydropyrimidin-1-yl)-N-(4-phenoxyphenyl)-acetamides as a novel class of cytomegalovirus replication inhibitors

2-(2,4-Dioxy-1,2,3,4-tetrahydropyrimidin-1-yl)-N-(4-phenoxyphenyl)-acetamides as a novel class of cytomegalovirus replication inhibitors

A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (A...

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Veröffentlicht in:Acta Naturae 2015-10, Vol.7 (4), p.142-5
Hauptverfasser: Babkov, D.A, Paramonova, M.P, Ozerov, A.A, Khandazhinskaya, A.L, Snoeck, Robert, Andrei, Graciela, Novikov, M.S
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of novel uracil derivatives, bearing N-(4-phenoxyphenyl)acetamide moiety at N3 of a pyrimidine ring, has been synthesized. Their antiviral activity has been evaluated. It has been found that the novel compounds possess high inhibitory activity against replication of human cytomegalovirus (AD-169 and Davis strains) in HEL cell cultures. In addition, some of the derivatives proved to be inhibitory against varicella zoster virus.
ISSN:2075-8251