Shear-resistant Binding to Von Willebrand Factor Allows Staphylococcus Lugdunensis to Adhere to the Cardiac Valves and Initiate Endocarditis

Staphylococcus lugdunensis (S. lugdunensis) is an emerging cause of endocarditis. To cause endovascular infections S. lugdunensis requires mechanisms to overcome shear stress. We investigated whether platelets and von Willebrand factor (VWF) mediate bacterial adhesion to the vessel wall and the card...

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Veröffentlicht in:The Journal of Infectious Diseases 2016-04, Vol.213 (7), p.1148-56
Hauptverfasser: Liesenborghs, Laurens, Peetermans, Marijke, Claes, Jorien, Veloso, Rafael, Vandenbriele, Christophe, Criel, Maarten, Lox, Marleen, Peetermans, Willy, Heilbronner, Simon, de Groot, Philip G, Vanassche, Thomas, Hoylaerts, Marc, Verhamme, Peter
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container_issue 7
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container_title The Journal of Infectious Diseases
container_volume 213
creator Liesenborghs, Laurens
Peetermans, Marijke
Claes, Jorien
Veloso, Rafael
Vandenbriele, Christophe
Criel, Maarten
Lox, Marleen
Peetermans, Willy
Heilbronner, Simon
de Groot, Philip G
Vanassche, Thomas
Hoylaerts, Marc
Verhamme, Peter
description Staphylococcus lugdunensis (S. lugdunensis) is an emerging cause of endocarditis. To cause endovascular infections S. lugdunensis requires mechanisms to overcome shear stress. We investigated whether platelets and von Willebrand factor (VWF) mediate bacterial adhesion to the vessel wall and the cardiac valves under flow.
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source Lirias (KU Leuven Association); Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection
title Shear-resistant Binding to Von Willebrand Factor Allows Staphylococcus Lugdunensis to Adhere to the Cardiac Valves and Initiate Endocarditis
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