Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies
Endometrial carcinoma (EC) is the sixth most common cancer in women and therapies are limited for advanced and recurrent disease. Patient-derived tumor xenograft (PDTX) models are becoming popular tools in translational research because of their histological and genetic similarity to the original tu...
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| Veröffentlicht in: | Gynecologic Oncology 2015-10, Vol.139 (1), p.118-26 |
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| creator | Depreeuw, Jeroen Hermans, Els Schrauwen, Stefanie Annibali, Daniela Coenegrachts, Lieve Thomas, Debby Luyckx, Mathieu Gutierrez-Roelens, Ilse Debruyne, David Konings, Katrien Moerman, Philippe Vergote, Ignace Lambrechts, Diether Amant, Frédéric |
| description | Endometrial carcinoma (EC) is the sixth most common cancer in women and therapies are limited for advanced and recurrent disease. Patient-derived tumor xenograft (PDTX) models are becoming popular tools in translational research because of their histological and genetic similarity to the original tumors and the ability to predict therapeutic response to treatments. Here, we established and characterized a panel of 24 EC PDTX models which includes the major histological and genetic subtypes observed in patients. |
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Patient-derived tumor xenograft (PDTX) models are becoming popular tools in translational research because of their histological and genetic similarity to the original tumors and the ability to predict therapeutic response to treatments. 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Patient-derived tumor xenograft (PDTX) models are becoming popular tools in translational research because of their histological and genetic similarity to the original tumors and the ability to predict therapeutic response to treatments. Here, we established and characterized a panel of 24 EC PDTX models which includes the major histological and genetic subtypes observed in patients.</abstract><pub>Academic Press</pub></addata></record> |
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| identifier | ISSN: 0090-8258 |
| ispartof | Gynecologic Oncology, 2015-10, Vol.139 (1), p.118-26 |
| issn | 0090-8258 |
| language | eng |
| recordid | cdi_kuleuven_dspace_123456789_503997 |
| source | Lirias (KU Leuven Association); ScienceDirect Journals (5 years ago - present) |
| title | Characterization of patient-derived tumor xenograft models of endometrial cancer for preclinical evaluation of targeted therapies |
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