Selectivity of aggregation-determining interactions

Protein aggregation is sequence specific, favoring self-assembly over cross-seeding with non-homologous sequences. Still, as the majority of proteins in a proteome are aggregation prone, the high level of homogeneity of protein inclusions in vivo both during recombinant overexpression and in disease...

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Veröffentlicht in:	Journal of Molecular Biology 2015-01, Vol.427 (2), p.236-47
Hauptverfasser:	Ganesan, Ashok, Debulpaep, Maja, Wilkinson, Hannah, Van Durme, Joost, De Baets, Greet, Jonckheere, Wim, Ramakers, Meine, Ivarsson, Ylva, Zimmermann, Pascale, Van Eldere, Johan, Schymkowitz, Joost, Rousseau, Frederic
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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