Scaffold hopping: Exploration of acetanilide-containing uracil analogues as potential NNRTIs

In order to identify novel nonnucleoside inhibitors of HIV-1 reverse transcriptase two series of amide-containing uracil derivatives were designed as hybrids of two scaffolds of previously reported inhibitors. Subsequent biological evaluation confirmed acetamide uracil derivatives 15a-k as selective...

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Veröffentlicht in:	Bioorganic & Medicinal Chemistry 2015-03, Vol.23 (5), p.1069-1081
Hauptverfasser:	Babkov, Denis A, Valuev-Elliston, Vladimir T, Paramonova, Maria P, Ozerov, Alexander A, Ivanov, Alexander V, Chizhov, Alexander O, Khandazhinskaya, Anastasia L, Kochetkov, Sergey N, Balzarini, Jan, Daelemans, Dirk, Pannecouque, Christophe, Seley-Radtke, Katherine L, Novikov, Mikhail S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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