Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia

Unique Tracheal Fluid MicroRNA Signature Predicts Response to FETO in Patients With Congenital Diaphragmatic Hernia

Our objective was to determine the fetal in vivo microRNA signature in hypoplastic lungs of human fetuses with severe isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetuses undergoing fetoscopic endoluminal tracheal occlusion (FETO) to reverse severe lun...

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Veröffentlicht in:Annals of Surgery 2015-12, Vol.262 (6), p.1130-40
Hauptverfasser: Pereira-Terra, Patrícia, Deprest, Jan, Kholdebarin, Ramin, Khoshgoo, Naghmeh, DeKoninck, Philip, Boerema-De Munck, Anne A, Wang, Jinxia, Zhu, Fuqin, Rottier, Robbert J, Iwasiow, Barbara M, Correia-Pinto, Jorge, Tibboel, Dick, Post, Martin, Keijzer, Richard
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Sprache:eng
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Zusammenfassung:Our objective was to determine the fetal in vivo microRNA signature in hypoplastic lungs of human fetuses with severe isolated congenital diaphragmatic hernia (CDH) and changes in tracheal and amniotic fluid of fetuses undergoing fetoscopic endoluminal tracheal occlusion (FETO) to reverse severe lung hypoplasia due to CDH.
ISSN:0003-4932