Imidazopyridine- and Purine-Thioacetamide Derivatives: Potent Inhibitors of Nucleotide Pyrophosphatase/Phosphodiesterase 1 (NPP1)

Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels. To study the (patho)physiological roles of NPP1 potent and selective inhibitors with drug-like properties are required. The...

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Veröffentlicht in:	Journal of Medicinal Chemistry 2014-12, Vol.57 (23), p.10080-100
Hauptverfasser:	Chang, Lei, Lee, Sang-Yong, Leonczak, Piotr, Rozenski, Jef, De Jonghe, Steven, Hanck, Theodor, Müller, Christa E, Herdewijn, Piet
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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