Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo

Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo

The pathogenesis of pulmonary fibrosis remains poorly understood. The Wnt signaling pathway regulates fibrogenesis in different organs. Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung fibrosis in...

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Veröffentlicht in:Fibrogenesis & Tissue Repair 2014-10, Vol.7 (1), p.1-10
Hauptverfasser: De Langhe, Ellen, Aznar Lopez, Carolina, De Vooght, Vanessa, Vanoirbeek, Jeroen, Luyten, Frank, Lories, Rik
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container_issue 1
container_start_page 1
container_title Fibrogenesis & Tissue Repair
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creator De Langhe, Ellen
Aznar Lopez, Carolina
De Vooght, Vanessa
Vanoirbeek, Jeroen
Luyten, Frank
Lories, Rik
description The pathogenesis of pulmonary fibrosis remains poorly understood. The Wnt signaling pathway regulates fibrogenesis in different organs. Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung fibrosis in vitro and in vivo. For this purpose, we used an alveolar epithelial cell line and a lung fibroblast cell line, and the bleomycin-induced lung fibrosis model, respectively.
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title Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo
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