Arthralgia induced by endocrine treatment for breast cancer: A prospective study of serum levels of insulin like growth factor-I, its binding protein and oestrogens

Arthralgia induced by endocrine treatment for breast cancer: A prospective study of serum levels of insulin like growth factor-I, its binding protein and oestrogens

Aromatase inhibitors (AIs) frequently induce or enhance musculoskeletal problems (AI-induced musculoskeletal syndrome (AIMSS)) which sometimes are debilitating. Apart from low oestrogen levels, underlying mechanisms are unknown and likely multiple. We previously hypothesised a role for the growth ho...

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Veröffentlicht in:European Journal of Cancer 2014-11, Vol.50 (17), p.2925-2931
Hauptverfasser: Lintermans, Anneleen, Vanderschueren, Dirk, Verhaeghe, Johan, Van Asten, Kathleen, Jans, Ivo, Van Herck, Erik, Laenen, Annouschka, Paridaens, Robert, Billen, Jaak, Pauwels, Steven, Vermeersch, Pieter, Wildiers, Hans, Christiaens, Rose, Neven, Patrick
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Sprache:eng
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Zusammenfassung:Aromatase inhibitors (AIs) frequently induce or enhance musculoskeletal problems (AI-induced musculoskeletal syndrome (AIMSS)) which sometimes are debilitating. Apart from low oestrogen levels, underlying mechanisms are unknown and likely multiple. We previously hypothesised a role for the growth hormone/insulin like growth factor-I (IGF-I) axis. Here, we report the effect of tamoxifen and AI on IGF-I, IGF binding protein-3 (IGFBP-3) and oestrogen levels from a prospective study.
ISSN:0959-8049