Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation

We performed a structure-activity relationship study of the antibiofilm plant-derived decapeptide OSIP108. Introduction of positively charged amino acids R, H, and K resulted in an up-to-5-fold-increased antibiofilm activity against Candida albicans compared to native OSIP108, whereas replacement of...

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2014-08, Vol.58 (8), p.4974-4977
Hauptverfasser:	Delattin, Nicolas, De Brucker, Katrijn, Craik, David, Cheneval, Oivier, De Coninck, Barbara, Cammue, Bruno, Thevissen, Karin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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