ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents

The flavin-dependent thymidylate synthase X (ThyX), rare in eukaryotes and completely absent in humans, is crucial in the metabolism of thymidine (a DNA precursor) in many microorganisms including several human pathogens. Conserved in mycobacteria, including Mycobacterium leprae, and Mycobacterium t...

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Veröffentlicht in:	Bioorganic & Medicinal Chemistry 2014-05, Vol.22 (9), p.2816-24
Hauptverfasser:	McGuigan, Christopher, Derudas, Marco, Gonczy, Blanka, Hinsinger, Karen, Kandil, Sahar, Pertusati, Fabrizio, Serpi, Michaela, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, McHugh, Timothy D, Maitra, Arundhati, Akorli, Ernest, Evangelopoulos, Dimitrios, Bhakta, Sanjib
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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