Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous...
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| Veröffentlicht in: | Science 2014-04, Vol.344 (6182), p.380-386 |
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| creator | Watanabe, Junichi Hattori, Masahira Berriman, Matthew Lehane, Michael Hall, Neil Solano, Philippe Aksoy, Serap Hide, Winston Touré, Yeya Attardo, Geoffrey Darby, Alistair Toyoda, Atsushi Hertz-Fowler, Christiane Larkin, Denis Cotton, James Sanders, Mandy Swain, Martin Quail, Michael Inoue, Noboru Ravel, Sophie Taylor, Todd Srivastava, Tulika Sharma, Vineet Warren, Wesley Wilson, Richard Suzuki, Yutaka Lawson, Daniel Hughes, Daniel Megy, Karyn Masiga, Daniel Mireji, Paul Hansen, Immo Van Den Abbeele, Jan Benoit, Joshua Bourtzis, Kostas Obiero, George Robertson, Hugh Jones, Jeffery Zhou, Jing-Jiang Field, Linda Friedrich, Markus Nyanjom, Steven Telleria, Erich Caljon, Guy Ribeiro, José Acosta-Serrano, Alvaro Ooi, Cher-Pheng Rose, Clair Price, David Haines, Lee Christoffels, Alan Sim, Cheolho Pham, Daphne Denlinger, David Geiser, Dawn Omedo, Irene Winzerling, Joy Peyton, Justin Marucha, Kevin Jonas, Mario Meuti, Megan Rawlings, Neil Zhang, Qirui Macharia, Rosaline Michalkova, Veronika Dashti, Zahra Baumann, Aaron Gäde, Gerd Marco, Heather Caers, Jelle Schoofs, Liliane Riehle, Michael Hu, Wanqi Tu, Zhijian Tarone, Aaron Malacrida, Anna Kibet, Caleb Scolari, Francesca Koekemoer, Jacobus Willis, Judith Gomulski, Ludvik Falchetto, Marco Scott, Maxwell Fu, Shuhua Sze, Sing-Hoi Luiz, Thiago Weiss, Brian Walshe, Deirdre Wang, Jingwen Wamalwa, Mark Mwangi, Sarah Ramphul, Urvashi Snyder, Anna Brelsfoard, Corey Thomas, Gavin Tsiamis, George Arensburger, Peter Rio, Rita Macdonald, Sandy Panji, Sumir |
| description | Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology. |
| format | Article |
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Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. 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Caleb</creatorcontrib><creatorcontrib>Scolari, Francesca</creatorcontrib><creatorcontrib>Koekemoer, Jacobus</creatorcontrib><creatorcontrib>Willis, Judith</creatorcontrib><creatorcontrib>Gomulski, Ludvik</creatorcontrib><creatorcontrib>Falchetto, Marco</creatorcontrib><creatorcontrib>Scott, Maxwell</creatorcontrib><creatorcontrib>Fu, Shuhua</creatorcontrib><creatorcontrib>Sze, Sing-Hoi</creatorcontrib><creatorcontrib>Luiz, Thiago</creatorcontrib><creatorcontrib>Weiss, Brian</creatorcontrib><creatorcontrib>Walshe, Deirdre</creatorcontrib><creatorcontrib>Wang, Jingwen</creatorcontrib><creatorcontrib>Wamalwa, Mark</creatorcontrib><creatorcontrib>Mwangi, Sarah</creatorcontrib><creatorcontrib>Ramphul, Urvashi</creatorcontrib><creatorcontrib>Snyder, Anna</creatorcontrib><creatorcontrib>Brelsfoard, Corey</creatorcontrib><creatorcontrib>Thomas, Gavin</creatorcontrib><creatorcontrib>Tsiamis, George</creatorcontrib><creatorcontrib>Arensburger, Peter</creatorcontrib><creatorcontrib>Rio, Rita</creatorcontrib><creatorcontrib>Macdonald, Sandy</creatorcontrib><creatorcontrib>Panji, Sumir</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Junichi</au><au>Hattori, Masahira</au><au>Berriman, Matthew</au><au>Lehane, Michael</au><au>Hall, Neil</au><au>Solano, Philippe</au><au>Aksoy, Serap</au><au>Hide, Winston</au><au>Touré, Yeya</au><au>Attardo, Geoffrey</au><au>Darby, Alistair</au><au>Toyoda, Atsushi</au><au>Hertz-Fowler, Christiane</au><au>Larkin, Denis</au><au>Cotton, James</au><au>Sanders, Mandy</au><au>Swain, Martin</au><au>Quail, Michael</au><au>Inoue, Noboru</au><au>Ravel, Sophie</au><au>Taylor, Todd</au><au>Srivastava, Tulika</au><au>Sharma, Vineet</au><au>Warren, Wesley</au><au>Wilson, Richard</au><au>Suzuki, Yutaka</au><au>Lawson, Daniel</au><au>Hughes, Daniel</au><au>Megy, Karyn</au><au>Masiga, Daniel</au><au>Mireji, Paul</au><au>Hansen, Immo</au><au>Van Den Abbeele, Jan</au><au>Benoit, Joshua</au><au>Bourtzis, Kostas</au><au>Obiero, George</au><au>Robertson, Hugh</au><au>Jones, Jeffery</au><au>Zhou, Jing-Jiang</au><au>Field, Linda</au><au>Friedrich, Markus</au><au>Nyanjom, Steven</au><au>Telleria, Erich</au><au>Caljon, Guy</au><au>Ribeiro, José</au><au>Acosta-Serrano, Alvaro</au><au>Ooi, Cher-Pheng</au><au>Rose, Clair</au><au>Price, David</au><au>Haines, Lee</au><au>Christoffels, Alan</au><au>Sim, Cheolho</au><au>Pham, Daphne</au><au>Denlinger, David</au><au>Geiser, Dawn</au><au>Omedo, Irene</au><au>Winzerling, Joy</au><au>Peyton, Justin</au><au>Marucha, Kevin</au><au>Jonas, Mario</au><au>Meuti, Megan</au><au>Rawlings, Neil</au><au>Zhang, Qirui</au><au>Macharia, Rosaline</au><au>Michalkova, Veronika</au><au>Dashti, Zahra</au><au>Baumann, Aaron</au><au>Gäde, Gerd</au><au>Marco, Heather</au><au>Caers, Jelle</au><au>Schoofs, Liliane</au><au>Riehle, Michael</au><au>Hu, Wanqi</au><au>Tu, Zhijian</au><au>Tarone, Aaron</au><au>Malacrida, Anna</au><au>Kibet, Caleb</au><au>Scolari, Francesca</au><au>Koekemoer, Jacobus</au><au>Willis, Judith</au><au>Gomulski, Ludvik</au><au>Falchetto, Marco</au><au>Scott, Maxwell</au><au>Fu, Shuhua</au><au>Sze, Sing-Hoi</au><au>Luiz, Thiago</au><au>Weiss, Brian</au><au>Walshe, Deirdre</au><au>Wang, Jingwen</au><au>Wamalwa, Mark</au><au>Mwangi, Sarah</au><au>Ramphul, Urvashi</au><au>Snyder, Anna</au><au>Brelsfoard, Corey</au><au>Thomas, Gavin</au><au>Tsiamis, George</au><au>Arensburger, Peter</au><au>Rio, Rita</au><au>Macdonald, Sandy</au><au>Panji, Sumir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis</atitle><jtitle>Science</jtitle><date>2014-04-25</date><risdate>2014</risdate><volume>344</volume><issue>6182</issue><spage>380</spage><epage>386</epage><pages>380-386</pages><issn>0036-8075</issn><abstract>Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.</abstract><pub>American Association for the Advancement of Science</pub><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science, 2014-04, Vol.344 (6182), p.380-386 |
| issn | 0036-8075 |
| language | eng |
| recordid | cdi_kuleuven_dspace_123456789_451787 |
| source | Lirias (KU Leuven Association); American Association for the Advancement of Science; Jstor Complete Legacy |
| title | Genome sequence of the tsetse fly (Glossina morsitans): vector of African trypanosomiasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T17%3A33%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-kuleuven&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genome%20sequence%20of%20the%20tsetse%20fly%20(Glossina%20morsitans):%20vector%20of%20African%20trypanosomiasis&rft.jtitle=Science&rft.au=Watanabe,%20Junichi&rft.date=2014-04-25&rft.volume=344&rft.issue=6182&rft.spage=380&rft.epage=386&rft.pages=380-386&rft.issn=0036-8075&rft_id=info:doi/&rft_dat=%3Ckuleuven%3E123456789_451787%3C/kuleuven%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |