Fused heterocyclic compounds bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 1: Design, synthesis and biological evaluation of novel 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives

In our continuous efforts to identify novel potent HIV-1 NNRTIs, a novel class of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives were rationally designed, synthesized and evaluated for their anti-HIV activities in MT4 cell cultures. Biological results showed that most of the tested compound...

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Veröffentlicht in:	Bioorganic & Medicinal Chemistry 2014-04, Vol.22 (7), p.2052-2059
Hauptverfasser:	Tian, Ye, Du, Deping, Rai, Diwakar, Wang, Liu, Liu, Huiqing, Zhan, Peng, De Clercq, Erik, Pannecouque, Christophe, Liu, Xinyong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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