A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

Therapeutic treatment of AIDS is recently characterized by a crescent effort towards the identification of multiple ligands able to target different steps of HIV-1 life cycle. Taking into consideration our previously obtained SAR information and combining some important chemical structural features...

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Veröffentlicht in:Bioorganic & Medicinal Chemistry 2014-02, Vol.22 (7), p.2269-2279
Hauptverfasser: Ferro, Stefania, De Luca, Laura, Lo Surdo, Giuseppa, Morreale, Francesca, Christ, Frauke, Debyser, Zeger, Gitto, Rosaria, Chimirri, Alba
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container_end_page 2279
container_issue 7
container_start_page 2269
container_title Bioorganic & Medicinal Chemistry
container_volume 22
creator Ferro, Stefania
De Luca, Laura
Lo Surdo, Giuseppa
Morreale, Francesca
Christ, Frauke
Debyser, Zeger
Gitto, Rosaria
Chimirri, Alba
description Therapeutic treatment of AIDS is recently characterized by a crescent effort towards the identification of multiple ligands able to target different steps of HIV-1 life cycle. Taking into consideration our previously obtained SAR information and combining some important chemical structural features we report herein the synthesis of novel benzyl-indole derivatives as anti-HIV agents. Through this work we identified new dual target small molecules able to inhibit both IN-LEDGF/p75 interaction and the IN strand-transfer step considered as two crucial phases of viral life cycle.
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title A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition
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