Improved synthesis of anhydrohexitol building blocks for oligonucleotide synthesis

Improved synthesis of anhydrohexitol building blocks for oligonucleotide synthesis

The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution reaction, whereas the pyrimidine nucleosides can best be obtained using Mitsunobu-type condi...

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Veröffentlicht in:Liebigs annalen-recueil 1997-07, Vol.1997 (7), p.1453-1461
Hauptverfasser: De Bouvere, B, Kerremans, Lucien, Rozenski, Jef, Janssen, Gerardus, Van Aerschot, Arthur, Claes, Paul, Busson, Roger, Herdewijn, Piet
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container_end_page 1461
container_issue 7
container_start_page 1453
container_title Liebigs annalen-recueil
container_volume 1997
creator De Bouvere, B
Kerremans, Lucien
Rozenski, Jef
Janssen, Gerardus
Van Aerschot, Arthur
Claes, Paul
Busson, Roger
Herdewijn, Piet
description The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution reaction, whereas the pyrimidine nucleosides can best be obtained using Mitsunobu-type conditions.
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identifier ISSN: 0947-3440
ispartof Liebigs annalen-recueil, 1997-07, Vol.1997 (7), p.1453-1461
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language eng
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source Lirias (KU Leuven Association); Wiley Online Library Journals Frontfile Complete
title Improved synthesis of anhydrohexitol building blocks for oligonucleotide synthesis
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