Reduced cortisol metabolism during critical illness

Reduced cortisol metabolism during critical illness

Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:New England Journal of Medicine 2013-04, Vol.368 (16), p.1477-1488
Hauptverfasser: Boonen, Eva, Vervenne, Hilke, Meersseman, Philippe, Andrew, Ruth, Mortier, Leentje, Declercq, Peter, Vanwijngaerden, Yoo-Mee, Spriet, Isabel, Wouters, Pieter, Vander Perre, Sarah, Langouche, Lies, Vanhorebeek, Ilse, Walker, Brian R, Van den Berghe, Greet
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Critical illness is often accompanied by hypercortisolemia, which has been attributed to stress-induced activation of the hypothalamic-pituitary-adrenal axis. However, low corticotropin levels have also been reported in critically ill patients, which may be due to reduced cortisol metabolism.
ISSN:0028-4793