Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension

Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension

UNLABELLED: We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/

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Veröffentlicht in:Hypertension 2001-04, Vol.37 (4), p.1069-1074
Hauptverfasser: Wang, J.G, Staessen, Jan A, Fagard, Robert, Birkenhäger, W.H, Gong, L, Liu, L, for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group
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container_end_page 1074
container_issue 4
container_start_page 1069
container_title Hypertension
container_volume 37
creator Wang, J.G
Staessen, Jan A
Fagard, Robert
Birkenhäger, W.H
Gong, L
Liu, L
for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group
description UNLABELLED: We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged >/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure >/=160/
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We used Cox regression to correlate outcome with baseline serum creatinine and uric acid measured in 1880 and 1873, respectively, of the 2394 patients enrolled in the placebo-controlled Systolic Hypertension in China (Syst-China) TRIAL: Median follow-up was 3 years. In multiple Cox regression analysis with adjustment for gender, age, active treatment, and other significant covariates, serum creatinine was significantly associated with a worse prognosis. The relative hazard rates (95% CIs) associated with a 20-micromol/L increase in serum creatinine for all-cause, cardiovascular, and stroke mortality were 1.16 (1.05 to 1.27, P=0.003), 1.15 (1.01 to 1.31, P=0.03), and 1.37 (1.13 to 1.65, P=0.001), respectively. In a similar analysis, which also accounted for serum creatinine, serum uric acid was also significantly and independently associated with excess mortality of cardiovascular disease and stroke. The relative hazard rates associated with a 50-micromol/L increase of serum uric acid were 1.14 (1.02 to 1.27, P=0.02) for cardiovascular mortality and 1.34 (1.14 to 1.57, P&lt;0.001) for fatal stroke. In conclusion, in older Chinese patients with isolated systolic hypertension, serum creatinine and serum uric acid were predictors of mortality.</description><identifier>ISSN: 0194-911X</identifier><language>eng</language><publisher>Lippincott Williams &amp; Wilkins</publisher><ispartof>Hypertension, 2001-04, Vol.37 (4), p.1069-1074</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,315,776,780,27837</link.rule.ids></links><search><creatorcontrib>Wang, J.G</creatorcontrib><creatorcontrib>Staessen, Jan A</creatorcontrib><creatorcontrib>Fagard, Robert</creatorcontrib><creatorcontrib>Birkenhäger, W.H</creatorcontrib><creatorcontrib>Gong, L</creatorcontrib><creatorcontrib>Liu, L</creatorcontrib><creatorcontrib>for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group</creatorcontrib><title>Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension</title><title>Hypertension</title><description>UNLABELLED: We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged &gt;/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure &gt;/=160/&lt;95 mm Hg). We used Cox regression to correlate outcome with baseline serum creatinine and uric acid measured in 1880 and 1873, respectively, of the 2394 patients enrolled in the placebo-controlled Systolic Hypertension in China (Syst-China) TRIAL: Median follow-up was 3 years. In multiple Cox regression analysis with adjustment for gender, age, active treatment, and other significant covariates, serum creatinine was significantly associated with a worse prognosis. The relative hazard rates (95% CIs) associated with a 20-micromol/L increase in serum creatinine for all-cause, cardiovascular, and stroke mortality were 1.16 (1.05 to 1.27, P=0.003), 1.15 (1.01 to 1.31, P=0.03), and 1.37 (1.13 to 1.65, P=0.001), respectively. In a similar analysis, which also accounted for serum creatinine, serum uric acid was also significantly and independently associated with excess mortality of cardiovascular disease and stroke. The relative hazard rates associated with a 50-micromol/L increase of serum uric acid were 1.14 (1.02 to 1.27, P=0.02) for cardiovascular mortality and 1.34 (1.14 to 1.57, P&lt;0.001) for fatal stroke. In conclusion, in older Chinese patients with isolated systolic hypertension, serum creatinine and serum uric acid were predictors of mortality.</description><issn>0194-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>FZOIL</sourceid><recordid>eNqVy7FOwzAQxnEPRWqhfYebOiBVihuXJnMFYmRgYIss-9IcmHPku1D69mTgAWD6hv_vW5hVZVu3a619W5pbkfeqss6548pcXko-cxalAEJnpp6C54CQexAs0yeEgl6JiRE8R5jKLH2gCMSQU8QCp2GOgjDODlkFLqQDkOTkFSPIVTSn-TVcRyyKLJR5bW56nwQ3v3tntk-Pr6fn3ceUcPpC7qKMPmBn97U7PBybtqvbxjb1P-D9n2Cn31r_APu7XC0</recordid><startdate>200104</startdate><enddate>200104</enddate><creator>Wang, J.G</creator><creator>Staessen, Jan A</creator><creator>Fagard, Robert</creator><creator>Birkenhäger, W.H</creator><creator>Gong, L</creator><creator>Liu, L</creator><creator>for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group</creator><general>Lippincott Williams &amp; Wilkins</general><scope>FZOIL</scope></search><sort><creationdate>200104</creationdate><title>Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension</title><author>Wang, J.G ; Staessen, Jan A ; Fagard, Robert ; Birkenhäger, W.H ; Gong, L ; Liu, L ; for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kuleuven_dspace_123456789_398183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, J.G</creatorcontrib><creatorcontrib>Staessen, Jan A</creatorcontrib><creatorcontrib>Fagard, Robert</creatorcontrib><creatorcontrib>Birkenhäger, W.H</creatorcontrib><creatorcontrib>Gong, L</creatorcontrib><creatorcontrib>Liu, L</creatorcontrib><creatorcontrib>for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group</creatorcontrib><collection>Lirias (KU Leuven Association)</collection><jtitle>Hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, J.G</au><au>Staessen, Jan A</au><au>Fagard, Robert</au><au>Birkenhäger, W.H</au><au>Gong, L</au><au>Liu, L</au><au>for the Systolic Hypertension in China (Syst-China) Trial Collaborative Group</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension</atitle><jtitle>Hypertension</jtitle><date>2001-04</date><risdate>2001</risdate><volume>37</volume><issue>4</issue><spage>1069</spage><epage>1074</epage><pages>1069-1074</pages><issn>0194-911X</issn><abstract>UNLABELLED: We examined the relation of serum creatinine and uric acid to mortality and cardiovascular disease in older (aged &gt;/=60 years) Chinese patients with isolated systolic hypertension (systolic/diastolic blood pressure &gt;/=160/&lt;95 mm Hg). We used Cox regression to correlate outcome with baseline serum creatinine and uric acid measured in 1880 and 1873, respectively, of the 2394 patients enrolled in the placebo-controlled Systolic Hypertension in China (Syst-China) TRIAL: Median follow-up was 3 years. In multiple Cox regression analysis with adjustment for gender, age, active treatment, and other significant covariates, serum creatinine was significantly associated with a worse prognosis. The relative hazard rates (95% CIs) associated with a 20-micromol/L increase in serum creatinine for all-cause, cardiovascular, and stroke mortality were 1.16 (1.05 to 1.27, P=0.003), 1.15 (1.01 to 1.31, P=0.03), and 1.37 (1.13 to 1.65, P=0.001), respectively. In a similar analysis, which also accounted for serum creatinine, serum uric acid was also significantly and independently associated with excess mortality of cardiovascular disease and stroke. The relative hazard rates associated with a 50-micromol/L increase of serum uric acid were 1.14 (1.02 to 1.27, P=0.02) for cardiovascular mortality and 1.34 (1.14 to 1.57, P&lt;0.001) for fatal stroke. In conclusion, in older Chinese patients with isolated systolic hypertension, serum creatinine and serum uric acid were predictors of mortality.</abstract><pub>Lippincott Williams &amp; Wilkins</pub><oa>free_for_read</oa></addata></record>
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title Prognostic significance of serum creatinine and uric acid in older Chinese patients with isolated systolic hypertension
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