HIV-1 X4 Activities of Polycationic "Viologen" Based Dendrimers by Interaction with the Chemokine Receptor CXCR4: Study of Structure-Activity Relationship

A series of "viologen" based dendrimers with polycationic scaffold carrying 10, 18, 26, 42, and 90 charges per molecule were used to determine the structure-activity relationship (SAR) with regard to HIV-1 inhibitory activity. The studies involved five compounds with a high activity agains...

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Veröffentlicht in:	Journal of Medicinal Chemistry 2012-12, Vol.55 (23), p.10405-10413
Hauptverfasser:	Asaftei, Simona, Huskens, Dana, Schols, Dominique
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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