Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-alpha in HTLV-1-Associated Myelopathy
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy i...
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| Veröffentlicht in: | PLoS Neglected Tropical Diseases 2012-07, Vol.6 (7) |
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| creator | Moens, Britta Decanine, Daniele Menezes, Soraya Khouri, Ricardo Silva-Santos, Gilvaneia Lopez, Giovanni Alvarez, Carolina Talledo, Michael Gotuzzo, Eduardo Kruschewsky, Ramon de Almeida Galvao-Castro, Bernardo Vandamme, Annemie Van Weyenbergh, Johan |
| description | Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial. However, there is a lack of in vivo and in vitro studies exploring and comparing the effects of high-dose AA and IFN-α treatment in the context of HAM/TSP. Therefore, we performed the first comparative analysis of the ex vivo and in vitro molecular and cellular mechanisms of action of IFN-α and high-dose AA in HAM/TSP. |
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| source | Lirias (KU Leuven Association); DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Public Library of Science (PLoS) |
| title | Ascorbic Acid Has Superior Ex Vivo Antiproliferative, Cell Death-Inducing and Immunomodulatory Effects over IFN-alpha in HTLV-1-Associated Myelopathy |
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